Evidence supporting the use of: Diindoylmethane
For the health condition: Fibroids (uterine)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, which is found in cruciferous vegetables. DIM is known for its effects on estrogen metabolism, specifically promoting the conversion of estrogen into less potent forms. Uterine fibroids are estrogen-sensitive, and therapies that modulate estrogen activity have been considered for their management.

There is limited but emerging scientific evidence suggesting DIM may have a role in supporting the management of uterine fibroids. Some in vitro studies and animal models indicate that DIM can inhibit the proliferation of uterine fibroid cells through modulation of estrogen metabolism and anti-inflammatory effects. DIM has also been shown to influence pathways involved in cell cycle regulation and apoptosis, which may contribute to reduced fibroid growth. However, clinical trials in humans are scarce: as of 2024, there are no large, well-designed randomized controlled trials demonstrating the efficacy or safety of DIM specifically for uterine fibroids.

While its use is theoretically plausible and supported by some preclinical evidence, DIM should not be considered a proven or primary therapy for fibroids. Its main support comes from mechanistic studies and anecdotal use in integrative medicine. Patients interested in DIM for fibroids should consult healthcare professionals and not use it as a substitute for evidence-based medical treatments.

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