Evidence supporting the use of: Curcuminoids
For the health condition: Fibromyalgia Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcuminoids, the active polyphenolic compounds in turmeric (Curcuma longa), have been researched primarily for their anti-inflammatory and antioxidant properties. Fibromyalgia Syndrome (FMS) is a chronic pain disorder associated with central sensitization, oxidative stress, and low-grade inflammation. Preliminary scientific studies suggest that curcuminoids may have a role in alleviating some fibromyalgia symptoms due to their capacity to modulate inflammatory cytokines and reduce oxidative stress.

A handful of small-scale clinical trials and animal studies have evaluated curcumin or turmeric extracts for chronic pain conditions, with a few pilot studies directly assessing their effects in fibromyalgia patients. Results indicate modest improvements in pain, fatigue, and quality of life measures, but these studies are limited by small sample sizes, short durations, and methodological weaknesses. Meta-analyses and systematic reviews of curcumin for chronic pain suggest potential benefit, but most evidence pertains to osteoarthritis and rheumatoid arthritis rather than fibromyalgia specifically.

Overall, while there is a plausible biological rationale and some preliminary clinical evidence supporting the use of curcuminoids for fibromyalgia, the scientific evidence base is still weak and insufficient to make strong clinical recommendations. High-quality, large-scale randomized controlled trials in FMS populations are lacking. Therefore, the evidence supporting curcuminoids for fibromyalgia is rated as low (2/5), reflecting early-stage scientific interest but not robust validation.

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