Evidence supporting the use of: Vitamin D
For the health condition: Fibrosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has a scientific basis for its use in supporting or treating fibrosis, though the evidence remains preliminary and largely preclinical, leading to a moderate-low rating (2/5) for its use. Fibrosis, characterized by excessive formation of connective tissue, occurs in various organs including the liver, lungs, and kidneys. Research has shown that vitamin D and its receptor (VDR) play a role in modulating immune response and suppressing pathways that lead to fibrogenesis. Studies in animal models have demonstrated that vitamin D supplementation or activation of VDR can reduce markers of fibrosis in the liver (such as in non-alcoholic fatty liver disease), lungs (such as in idiopathic pulmonary fibrosis), and kidneys. These effects are thought to be mediated by vitamin D’s ability to inhibit transforming growth factor-beta (TGF-β) signaling, a central pathway in fibrosis development, as well as by reducing inflammation and oxidative stress.

However, while in vitro and animal studies provide promising data, clinical evidence in humans is limited and inconsistent. Some small-scale clinical studies have observed that low vitamin D levels are associated with increased fibrosis severity, and vitamin D supplementation may have beneficial effects on fibrosis markers. Nevertheless, high-quality randomized controlled trials showing clear therapeutic benefit are lacking. Thus, while there is a scientific rationale and some supporting evidence for vitamin D use in fibrosis, its use is not yet considered standard or evidence-based medical practice for this indication.

More about vitamin D
More about Fibrosis

Other health conditions supported by vitamin D

Acne
Allergies (food)
Allergies (respiratory)
Alzheimer's Disease
Amenorrhea
Anemia
Anorexia
Apathy
Arrhythmia
Arteriosclerosis
Arthritis
Asthma
Autism
Autoimmune Disorders
Backache
Birth Defects (prevention)
Body Building
Broken Bones
Calcium Deficiency
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cardiovascular Disease
Celiac Disease
Chronic Obstructive Pulmonary Disorder
Colds (antiviral)
Colds (general)
Colds (prevention)
Colds (with fever)
Concentration (poor)
Concussions
Confusion
Congestive Heart Failure
Contagious Diseases
Convalescence
Convulsions
Cramps (menstrual)
Cramps and Spasms
Crohn's Disease
Cystic Breast Disease
Cystic Fibrosis
Dandruff
Debility
Dementia
Depression
Dermatitis
Diabetes
Diabetic Retinopathy
Erectile Dysfunction
Estrogen (low)
Fatigue
Fibroids (uterine)
Fibromyalgia Syndrome
Fibrosis
Grave's Disease
Grief and Sadness
Hair (loss or thinning)
Hair Care (general)
Hashimoto's Disease
Headache (cluster)
Heart (weakness)
Hypertension
Hypothyroid
Infection
Infection (bacterial)
Infection (viral)
Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Irritable Bowel Syndrome
Itching
Knees (weak)
Leaky Gut Syndrome
Leprosy
Lesions
Leukemia
Lou Gehrig's Disease
Lupus
Lymphoma
Melanoma
Memory and Brain Function
Menopause
Menstrual Irregularity
Mental Illness
Metabolic Syndrome
Migraine
Miscarriage (prevention)
Mood Swings
Multiple Sclerosis
Muscle Tone (lack of)
Muscular Dystrophy
Myasthenia Gravis
Nephritis
Nerve Damage
Nervous Exhaustion
Numbness
Nursing
Obsessive Compulsive Disorder
Oral Surgery
Osteoporosis
Pain (general remedies for)
Pancreatitis
Paralysis
Parkinson's Disease
Peripheral Neuropathy
PMS (general)
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Pneumonia
Polyps
Post Partum Depression
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Prostatitis
Psoriasis
Rheumatoid Arthritis
Schizophrenia
Sciatica
Seasonal Affective Disorder
Senility
Tuberculosis