Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha-glycosyl isoquercitrin (AGIQ) is a highly bioavailable derivative of quercetin, a well-known flavonoid with potent antioxidant properties. The rationale for its use in supporting or mitigating free radical damage is primarily based on scientific evidence. Quercetin itself has been extensively studied for its ability to scavenge reactive oxygen species (ROS) and protect cells from oxidative stress, which is a key contributor to free radical damage. However, quercetin's poor solubility and bioavailability have limited its clinical utility. AGIQ addresses this limitation by adding glycosyl groups, significantly improving its water solubility and absorption in the human body.

Several preclinical studies have demonstrated that AGIQ retains or even enhances the antioxidant activity of quercetin. For example, research has shown that AGIQ can effectively increase antioxidant capacity in vitro and in animal models by reducing markers of oxidative stress such as lipid peroxidation and oxidized glutathione. Some small-scale human studies and randomized controlled trials suggest that AGIQ supplementation can increase plasma antioxidant levels and decrease biomarkers of oxidative damage, but large-scale clinical evidence is still lacking.

Overall, while the mechanistic rationale and preclinical data are strong, and early human studies are promising, the evidence base is not yet robust enough (hence the rating of 3/5) to claim unequivocal clinical benefit. Nevertheless, AGIQ is widely used in functional foods and dietary supplements for its antioxidant potential and is scientifically justified in the context of supporting the body’s defense against free radical damage.

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