Evidence supporting the use of: Alpha-lipoic acid
For the health condition: Free Radical Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha-Lipoic Acid and Free Radical Damage: Scientific Evidence

Alpha-lipoic acid (ALA) is a naturally occurring compound that functions as a cofactor in mitochondrial energy metabolism and is recognized for its antioxidant properties. Scientific interest in ALA centers on its ability to neutralize free radicals—unstable molecules that can cause oxidative damage to cells and tissues, a process implicated in aging and various diseases.

ALA is unique among antioxidants because it is both water- and fat-soluble, allowing it to act in almost every part of the cell. It can also regenerate other antioxidants, such as vitamins C and E, further enhancing its protective effects. Several laboratory and animal studies have demonstrated that ALA can reduce oxidative stress by scavenging reactive oxygen species and by increasing levels of intracellular glutathione, a key antioxidant molecule.

In humans, clinical trials have explored the use of ALA primarily in conditions associated with oxidative stress, such as diabetic neuropathy and metabolic syndrome. Some studies report improvements in oxidative stress markers and symptoms, suggesting that ALA supplementation may help mitigate free radical damage. However, the evidence in healthy populations or for general antioxidant support is less robust. The overall quality and consistency of clinical evidence is moderate, which justifies a rating of 3 out of 5.

In summary, while ALA's antioxidant activity is well-supported by mechanistic and preclinical studies, human clinical evidence is moderate and most compelling in certain disease contexts rather than for broad prevention.

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Other ingredients used for Free Radical Damage

1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose
3,3'-dihydroxy-B-carotene-4,4'-dione
3-Isomangostin
5,7-Dimethoxyflavone
7,4-Dimethoxyflavone
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Acacetin
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alpha-lipoic acid
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Products containing alpha-lipoic acid

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