Evidence supporting the use of: Benfotiamine
For the health condition: Free Radical Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Benfotiamine is a synthetic derivative of thiamine (vitamin B1) that has been studied for its potential to mitigate free radical damage, particularly in the context of diabetes and related complications. Scientific interest in benfotiamine centers around its ability to increase thiamine levels more effectively than standard thiamine supplements and to modulate pathways involved in oxidative stress and advanced glycation end-product (AGE) formation. Preclinical studies suggest that benfotiamine can reduce oxidative stress markers and inhibit the formation of AGEs, which are known to contribute to free radical production and tissue damage, particularly in hyperglycemic states.

Some small clinical trials have reported that benfotiamine supplementation improves markers of oxidative stress and endothelial function in patients with diabetes. For instance, studies have shown that benfotiamine can decrease plasma levels of AGEs and improve antioxidant capacity. However, these studies are generally limited in scope, sample size, and duration. There is a lack of large-scale, long-term clinical trials directly demonstrating that benfotiamine reduces clinical endpoints related to free radical damage in humans.

Overall, while there is some mechanistic and preliminary clinical evidence suggesting that benfotiamine may help reduce free radical damage, especially in diabetic populations, the evidence is not robust or conclusive. Therefore, its use for this purpose is rated as “2” for evidence strength, indicating limited but present scientific support.

More about benfotiamine
More about Free Radical Damage

Other ingredients used for Free Radical Damage

1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose
3,3'-dihydroxy-B-carotene-4,4'-dione
3-Isomangostin
5,7-Dimethoxyflavone
7,4-Dimethoxyflavone
7-hydroxymatairesinol (HMR)
Acacetin
Acai berry
Acer truncatum
Acetyl L-carnitine
Algae
Algal protein
Allophycocyanin
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-lipoic acid
amentoflavone
amethoflavone
amino acids
ankaflavin
anthocyanidins
anthocyanins
anthocyanosides
antirrhinin
apigenin
apocarotenal
apocynin
apricot
arctiin
argan nut oil
Arjunolic acid
Aronia melanocarpa
ascorbigen
ascorbyl palmitate
astaxanthin
astragaloside
astragalus
Auricularia
Autumn Olive
avocado
baccosides
bacoside
baicalin
Basidiomycota
basil
bee pollen
benfotiamine
berry
beta-carotene
beta-hydroxybutyrate
beta-tocopherol
beta-zeacarotene
betanin
BHA (butylated hydroxyanisole)
BHT (butylated hydroxytoluene)
bilberry
bioflavonoids
black currant
black garlic
black tea
blackberry
blueberry
bok choy
boysenberry
Brassica
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broccoli
Brussel sprouts
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
camu camu
canthaxanthin
capsanthin
capsorubin
carnosic acid
Carnosine
carnosol
carotene (unspecified)
cashew
catalase
catechins
caterpillar mushroom
cauliflower
chebulic acid
chebulinic acid
chocolate
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cistanche
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crocetin
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dehydroascorbic acid
delphinidin
delta-tocopherol
desoxyrhaponticin
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Dumontiaceae
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fruit blend (proprietary)
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guarana
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Zinc

Products containing benfotiamine

We currently have no products on Vitabase that contain this ingredient.