Evidence supporting the use of: Hydroxycinnamic acid
For the health condition: Free Radical Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hydroxycinnamic acids, a group of naturally occurring phenolic compounds (including caffeic acid, ferulic acid, and p-coumaric acid), have received considerable scientific attention for their antioxidant properties and their potential role in mitigating free radical damage. Several in vitro and animal studies have demonstrated that hydroxycinnamic acids can effectively scavenge reactive oxygen species (ROS) and inhibit lipid peroxidation, mechanisms that are directly linked to the reduction of oxidative stress and free radical-induced cellular damage.

For example, research published in peer-reviewed journals such as Food & Function and Journal of Agricultural and Food Chemistry has shown that these acids can increase cellular antioxidant defenses and reduce markers of oxidative damage. Moreover, hydroxycinnamic acids are abundant in dietary sources like coffee, whole grains, fruits, and vegetables, and their intake is associated in epidemiological studies with reduced risk of chronic diseases where free radical damage is implicated, such as cardiovascular disease and certain cancers.

However, while the biochemical and preclinical evidence is robust, clinical trials directly demonstrating a clear benefit of hydroxycinnamic acid supplementation in reducing free radical damage or improving related health outcomes in humans are limited. Thus, while the scientific rationale is strong, further human studies are needed to firmly establish their efficacy for this purpose, justifying a moderate evidence rating.

More about hydroxycinnamic acid
More about Free Radical Damage

Other ingredients used for Free Radical Damage

1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose
3,3'-dihydroxy-B-carotene-4,4'-dione
3-Isomangostin
5,7-Dimethoxyflavone
7,4-Dimethoxyflavone
7-hydroxymatairesinol (HMR)
Acacetin
Acai berry
Acer truncatum
Acetyl L-carnitine
Algae
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Allophycocyanin
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-lipoic acid
amentoflavone
amethoflavone
amino acids
ankaflavin
anthocyanidins
anthocyanins
anthocyanosides
antirrhinin
apigenin
apocarotenal
apocynin
apricot
arctiin
argan nut oil
Arjunolic acid
Aronia melanocarpa
ascorbigen
ascorbyl palmitate
astaxanthin
astragaloside
astragalus
Auricularia
Autumn Olive
avocado
baccosides
bacoside
baicalin
Basidiomycota
basil
bee pollen
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berry
beta-carotene
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betanin
BHA (butylated hydroxyanisole)
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bilberry
bioflavonoids
black currant
black garlic
black tea
blackberry
blueberry
bok choy
boysenberry
Brassica
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broccoli
Brussel sprouts
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
camu camu
canthaxanthin
capsanthin
capsorubin
carnosic acid
Carnosine
carnosol
carotene (unspecified)
cashew
catalase
catechins
caterpillar mushroom
cauliflower
chebulic acid
chebulinic acid
chocolate
chokeberry
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cichoric acid
cistanche
cocoa
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coenzyme Q10 (CoQ10)
coffee fruit
crocetin
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cupric ascorbate
dehydroascorbic acid
delphinidin
delta-tocopherol
desoxyrhaponticin
dibenzo-alpha pyrones
dihydrolipoic acid
diosmetin
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dragon fruit
Dumontiaceae
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emblicanin
epicatechin
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ergothioneine
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ethylgallate
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fruit blend (proprietary)
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ginseng
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grape
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guarana
Haematococcus pluvialis
hesperetin
hesperidin
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hydroxycinnamic acid
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hydroxytyrosol
Idebenone
isoascorbate
isovitexin
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oyster mushroom
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Products containing hydroxycinnamic acid

We currently have no products on Vitabase that contain this ingredient.