Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Synopsis: L-glutathione is a tripeptide composed of glutamine, cysteine, and glycine, and is one of the body’s most important endogenous antioxidants. Its primary role is to neutralize free radicals and reactive oxygen species (ROS), thereby preventing oxidative stress and cellular damage. Scientific studies provide substantial evidence supporting the use of L-glutathione for combating free radical damage. Both in vitro and in vivo research have demonstrated that glutathione directly scavenges free radicals and is involved in the regeneration of other antioxidants such as vitamins C and E. Clinical studies also show that depleted glutathione levels are associated with increased oxidative stress and a higher risk for chronic diseases, including neurodegenerative disorders, cardiovascular diseases, and certain cancers. Supplementation or dietary strategies to boost glutathione levels have been shown to increase antioxidant capacity, reduce biomarkers of oxidative stress, and in some cases, improve clinical outcomes. However, oral bioavailability of glutathione is a subject of ongoing research, and some studies suggest that precursor supplementation (e.g., N-acetylcysteine) may be more effective for raising systemic glutathione. Nevertheless, the mechanistic and clinical data provide scientific validation for the use of L-glutathione in support and treatment of free radical damage, earning it a high evidence rating.

More about l-glutathione
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Other ingredients used for Free Radical Damage

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