Evidence supporting the use of: Neoandrographolides
For the health condition: Free Radical Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Neoandrographolide is a major bioactive compound found in Andrographis paniculata, a plant traditionally used in Asian medicine. The interest in neoandrographolide for supporting or treating free radical damage (oxidative stress) is primarily based on preclinical scientific studies. Several in vitro and animal studies have demonstrated that neoandrographolide exhibits antioxidant activity. These studies suggest that neoandrographolide can scavenge free radicals, enhance endogenous antioxidant enzyme activities (such as superoxide dismutase and catalase), and reduce biomarkers of oxidative stress in animal models. For example, research has shown that neoandrographolide reduces oxidative damage in liver and brain tissues of rodents exposed to toxic agents.

However, the evidence is limited to laboratory and animal research; there are no robust clinical trials in humans specifically evaluating neoandrographolide’s efficacy against free radical damage. The findings from preclinical data provide a mechanistic rationale for its use but do not establish clinical effectiveness or safety for this purpose in humans. In summary, while there is scientific interest and foundational research supporting the antioxidant potential of neoandrographolide, the level of evidence remains low (rated 2/5) due to the lack of human studies.

More about Neoandrographolides
More about Free Radical Damage

Other ingredients used for Free Radical Damage

1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose
3,3'-dihydroxy-B-carotene-4,4'-dione
3-Isomangostin
5,7-Dimethoxyflavone
7,4-Dimethoxyflavone
7-hydroxymatairesinol (HMR)
Acacetin
Acai berry
Acer truncatum
Acetyl L-carnitine
Algae
Algal protein
Allophycocyanin
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-lipoic acid
amentoflavone
amethoflavone
amino acids
ankaflavin
anthocyanidins
anthocyanins
anthocyanosides
antirrhinin
apigenin
apocarotenal
apocynin
apricot
arctiin
argan nut oil
Arjunolic acid
Aronia melanocarpa
ascorbigen
ascorbyl palmitate
astaxanthin
astragaloside
astragalus
Auricularia
Autumn Olive
avocado
baccosides
bacoside
baicalin
Basidiomycota
basil
bee pollen
benfotiamine
berry
beta-carotene
beta-hydroxybutyrate
beta-tocopherol
beta-zeacarotene
betanin
BHA (butylated hydroxyanisole)
BHT (butylated hydroxytoluene)
bilberry
bioflavonoids
black currant
black garlic
black tea
blackberry
blueberry
bok choy
boysenberry
Brassica
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broccoli
Brussel sprouts
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
camu camu
canthaxanthin
capsanthin
capsorubin
carnosic acid
Carnosine
carnosol
carotene (unspecified)
cashew
catalase
catechins
caterpillar mushroom
cauliflower
chebulic acid
chebulinic acid
chocolate
chokeberry
chrysin
cichoric acid
cistanche
cocoa
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coenzyme Q10 (CoQ10)
coffee fruit
crocetin
Crypthecodinium
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cupric ascorbate
dehydroascorbic acid
delphinidin
delta-tocopherol
desoxyrhaponticin
dibenzo-alpha pyrones
dihydrolipoic acid
diosmetin
dismutase
dragon fruit
Dumontiaceae
Dunaliella
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Ecklonia
ellagic acid
emblicanin
epicatechin
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ergothioneine
eriodictyol
erythorbic acid
ethylgallate
fatty acids
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fish protein
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fruit blend (proprietary)
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ginseng
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goji berry
grape
green tea
greens blend (proprietary)
guarana
Haematococcus pluvialis
hesperetin
hesperidin
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hydroxycinnamic acid
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hydroxytyrosol
Idebenone
isoascorbate
isovitexin
Jaboticaba
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mixed carotenoids
Myricitrin
N-acetyl-cysteine (NAC)
N-Caffeoyldopamine
Neoandrographolides
Neoxanthin
nicotinamide riboside
Oligomeric proanthocyanidins
omega-3 fatty acids
oyster mushroom
papaya
Pecan
Pentacyclic triterpenoids
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royal jelly
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selenium
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turmeric
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ubiquinol
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vegetable blend (proprietary)
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vitamin C
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Xylaria nigripes
Yumberry
Zinc

Products containing Neoandrographolides

We currently have no products on Vitabase that contain this ingredient.