Evidence supporting the use of: Procyanidol
For the health condition: Free Radical Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Procyanidol, also known as procyanidolic oligomers or procyanidins, are a class of polyphenolic compounds commonly found in plants such as grape seeds, pine bark, and cocoa. Their use to support or treat free radical damage is primarily backed by scientific evidence. Numerous in vitro and animal studies have demonstrated that procyanidins possess strong antioxidant properties, enabling them to scavenge free radicals and reduce oxidative stress. They act by donating hydrogen atoms or electrons to neutralize reactive oxygen species (ROS), thereby protecting cellular components like lipids, proteins, and DNA from oxidative damage.

Clinical trials in humans, though fewer in number, indicate that supplementation with procyanidins (especially from grape seed extract) can improve biomarkers of oxidative stress, such as lowering lipid peroxidation and enhancing the activity of endogenous antioxidant enzymes (e.g., superoxide dismutase, glutathione peroxidase). However, most clinical studies involve relatively small sample sizes and short durations.

Overall, while there is substantial preclinical evidence and some supportive human data suggesting that procyanidins help counteract free radical damage, more large-scale and long-term clinical trials are needed to confirm their efficacy and safety in diverse populations. Nevertheless, the mechanistic plausibility and consistency of findings across studies justify their scientific use for supporting the body against free radical damage.

More about procyanidol
More about Free Radical Damage

Other ingredients used for Free Radical Damage

1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose
3,3'-dihydroxy-B-carotene-4,4'-dione
3-Isomangostin
5,7-Dimethoxyflavone
7,4-Dimethoxyflavone
7-hydroxymatairesinol (HMR)
Acacetin
Acai berry
Acer truncatum
Acetyl L-carnitine
Algae
Algal protein
Allophycocyanin
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-lipoic acid
amentoflavone
amethoflavone
amino acids
ankaflavin
anthocyanidins
anthocyanins
anthocyanosides
antirrhinin
apigenin
apocarotenal
apocynin
apricot
arctiin
argan nut oil
Arjunolic acid
Aronia melanocarpa
ascorbigen
ascorbyl palmitate
astaxanthin
astragaloside
astragalus
Auricularia
Autumn Olive
avocado
baccosides
bacoside
baicalin
Basidiomycota
basil
bee pollen
benfotiamine
berry
beta-carotene
beta-hydroxybutyrate
beta-tocopherol
beta-zeacarotene
betanin
BHA (butylated hydroxyanisole)
BHT (butylated hydroxytoluene)
bilberry
bioflavonoids
black currant
black garlic
black tea
blackberry
blueberry
bok choy
boysenberry
Brassica
Brazil nut
broccoli
Brussel sprouts
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
camu camu
canthaxanthin
capsanthin
capsorubin
carnosic acid
Carnosine
carnosol
carotene (unspecified)
cashew
catalase
catechins
caterpillar mushroom
cauliflower
chebulic acid
chebulinic acid
chocolate
chokeberry
chrysin
cichoric acid
cistanche
cocoa
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
crocetin
Crypthecodinium
cryptoxanthin
cupric ascorbate
dehydroascorbic acid
delphinidin
delta-tocopherol
desoxyrhaponticin
dibenzo-alpha pyrones
dihydrolipoic acid
diosmetin
dismutase
dragon fruit
Dumontiaceae
Dunaliella
Dunaliella salina
Ecklonia
ellagic acid
emblicanin
epicatechin
epigallocatechin gallate (EGCG)
ergothioneine
eriodictyol
erythorbic acid
ethylgallate
fatty acids
ferulic acid
fish protein
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flavans
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flavoglycosides
flavones
flavonols
flavonones
fruit blend (proprietary)
fucoidan
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Gac
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gamma-glutamylcysteine
ganoderma
Garcinone C
Garcinone E
ginseng
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Glutathione
goji berry
grape
green tea
greens blend (proprietary)
guarana
Haematococcus pluvialis
hesperetin
hesperidin
HMR lignan
honeybush
hydroxycinnamic acid
hydroxyphenylethanols
hydroxytyrosol
Idebenone
isoascorbate
isovitexin
Jaboticaba
Kaempferol
kucha tea
L-carnosine
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Lentinula edodes mycelia
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lingzhi
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lutein
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Matcha
Mate
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Methoxylated flavones
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Mineral ascorbate
mixed carotenoids
Myricitrin
N-acetyl-cysteine (NAC)
N-Caffeoyldopamine
Neoandrographolides
Neoxanthin
nicotinamide riboside
Oligomeric proanthocyanidins
omega-3 fatty acids
oyster mushroom
papaya
Pecan
Pentacyclic triterpenoids
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phenolic compounds
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phospholipids
Phthalides
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Phytoplankton
pine bark
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Pleurotus eryngii
polymethoxylated flavones
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polyporous mushroom
proanthocyanidins
procyanidin
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propyl gallate
punicalagins
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pyrroloquinoline disodium salt
pyrroloquinoline quinone
quercetin
raspberry
reishi mushroom
resveratrol
rhammetin
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rosmarinic acid
royal jelly
Salidroside
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selenium
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spirulina
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strawberry
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Trigalloyl glucose
turmeric
Tyrosol
ubiquinol
Uncaria
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vegetable blend (proprietary)
Vestitol
vitamin C
vitamin E
Walnut
wheat germ
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Withanolides
Xanthone
Xanthophyll
Xylaria nigripes
Yumberry
Zinc

Products containing procyanidol

We currently have no products on Vitabase that contain this ingredient.