Evidence supporting the use of: Quercetin
For the health condition: Free Radical Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Quercetin is a plant-derived flavonoid widely recognized for its antioxidant properties. Scientific evidence supports its role in mitigating free radical damage, primarily through in vitro and animal studies. Quercetin acts as a potent scavenger of reactive oxygen species (ROS), neutralizing free radicals and thereby reducing oxidative stress. Multiple studies have shown that quercetin can protect cell membranes and biomolecules such as DNA and lipids from oxidative damage. For example, a review published in Oxidative Medicine and Cellular Longevity (2016) summarized the antioxidant mechanisms of quercetin, highlighting its ability to chelate metal ions, upregulate endogenous antioxidant enzymes like superoxide dismutase and catalase, and interrupt free radical chain reactions.

However, while laboratory and animal studies are promising, evidence from human clinical trials is less robust. Some small-scale human studies suggest that quercetin supplementation can decrease biomarkers of oxidative stress, especially in individuals with higher baseline oxidative damage (such as athletes or people with metabolic syndrome). Nonetheless, large, well-controlled human trials are limited, and the bioavailability of quercetin in the human body is relatively low, which may impact its effectiveness. Overall, quercetin’s use for supporting or treating free radical damage is scientifically justified, with a moderate level of evidence based mainly on preclinical research, and growing but still limited clinical validation.

More about quercetin
More about Free Radical Damage

Other ingredients used for Free Radical Damage

1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose
3,3'-dihydroxy-B-carotene-4,4'-dione
3-Isomangostin
5,7-Dimethoxyflavone
7,4-Dimethoxyflavone
7-hydroxymatairesinol (HMR)
Acacetin
Acai berry
Acer truncatum
Acetyl L-carnitine
Algae
Algal protein
Allophycocyanin
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-lipoic acid
amentoflavone
amethoflavone
amino acids
ankaflavin
anthocyanidins
anthocyanins
anthocyanosides
antirrhinin
apigenin
apocarotenal
apocynin
apricot
arctiin
argan nut oil
Arjunolic acid
Aronia melanocarpa
ascorbigen
ascorbyl palmitate
astaxanthin
astragaloside
astragalus
Auricularia
Autumn Olive
avocado
baccosides
bacoside
baicalin
Basidiomycota
basil
bee pollen
benfotiamine
berry
beta-carotene
beta-hydroxybutyrate
beta-tocopherol
beta-zeacarotene
betanin
BHA (butylated hydroxyanisole)
BHT (butylated hydroxytoluene)
bilberry
bioflavonoids
black currant
black garlic
black tea
blackberry
blueberry
bok choy
boysenberry
Brassica
Brazil nut
broccoli
Brussel sprouts
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
camu camu
canthaxanthin
capsanthin
capsorubin
carnosic acid
Carnosine
carnosol
carotene (unspecified)
cashew
catalase
catechins
caterpillar mushroom
cauliflower
chebulic acid
chebulinic acid
chocolate
chokeberry
chrysin
cichoric acid
cistanche
cocoa
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
crocetin
Crypthecodinium
cryptoxanthin
cupric ascorbate
dehydroascorbic acid
delphinidin
delta-tocopherol
desoxyrhaponticin
dibenzo-alpha pyrones
dihydrolipoic acid
diosmetin
dismutase
dragon fruit
Dumontiaceae
Dunaliella
Dunaliella salina
Ecklonia
ellagic acid
emblicanin
epicatechin
epigallocatechin gallate (EGCG)
ergothioneine
eriodictyol
erythorbic acid
ethylgallate
fatty acids
ferulic acid
fish protein
flavanones
flavans
flavin mononucleotide
flavoglycosides
flavones
flavonols
flavonones
fruit blend (proprietary)
fucoidan
fulvic acid
furanosterols
Gac
gamma-carotene
gamma-glutamylcysteine
ganoderma
Garcinone C
Garcinone E
ginseng
Ginsenosides
Glucan peptides
Glutathione
goji berry
grape
green tea
greens blend (proprietary)
guarana
Haematococcus pluvialis
hesperetin
hesperidin
HMR lignan
honeybush
hydroxycinnamic acid
hydroxyphenylethanols
hydroxytyrosol
Idebenone
isoascorbate
isovitexin
Jaboticaba
Kaempferol
kucha tea
L-carnosine
L-cysteine
L-glutathione
L-glycine
Lentinula edodes mycelia
Leucodelphinidin
lingzhi
lipids
lutein
Lycium
macadamia
malvidin
mangiferin
mangostanol
mangostene xanthone
Matcha
Mate
Melatonin
Methoxylated flavones
Methylselenocysteine
Mineral ascorbate
mixed carotenoids
Myricitrin
N-acetyl-cysteine (NAC)
N-Caffeoyldopamine
Neoandrographolides
Neoxanthin
nicotinamide riboside
Oligomeric proanthocyanidins
omega-3 fatty acids
oyster mushroom
papaya
Pecan
Pentacyclic triterpenoids
Pentose phosphate
phenolic compounds
Phosphate ascorbate
phospholipids
Phthalides
Phycocyanin
Phytoene
Phytofluene
Phytoplankton
pine bark
Plankton
Pleurotus eryngii
polymethoxylated flavones
polyphenols
polyporous mushroom
proanthocyanidins
procyanidin
procyanidol
propyl gallate
punicalagins
punicosides
Pycnogenol
pyrroloquinoline disodium salt
pyrroloquinoline quinone
quercetin
raspberry
reishi mushroom
resveratrol
rhammetin
Ribose-l-cysteine
robusta coffee
Rooibos
rosmarinic acid
royal jelly
Salidroside
Schisandrins
Scopoletin
selenium
Sesamolin
Shilajit
Silychristin
spirulina
Squalene
strawberry
Tangeretin
Taxifolin
Theaflavin
Tiliroside
Tremella
Trigalloyl glucose
turmeric
Tyrosol
ubiquinol
Uncaria
Vanillin
vegetable blend (proprietary)
Vestitol
vitamin C
vitamin E
Walnut
wheat germ
Whey protein
White Tea
Withanolides
Xanthone
Xanthophyll
Xylaria nigripes
Yumberry
Zinc

Products containing quercetin

Pure Encapsulations Acerola/Flavonoid
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Pure Encapsulations AI Formula
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Pure Encapsulations Balanced Immune
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Designs For Health C+BioFizz®
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Designs For Health DFH Complete Multi™
Designs For Health DFH Complete Multi™ with Copper
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Designs For Health DopaBoost™
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Pure Encapsulations Essential-C & Flavonoids
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Designs For Health GI Revive®
Designs For Health GI Revive®
Designs For Health H-S-N Radiance™
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Designs For Health HistaEze™
Metagenics Immune Active
Metagenics Immune Defense Pack
Designs For Health Inflammatone™
Designs For Health Inflammatone™
Designs For Health Inflammatone™
Vitabase Life's Essentials Plus
Metagenics Multigenics®
Metagenics Multigenics Chewable Orange
Metagenics Multigenics Intensive Care
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Metagenics Multigenics without Iron
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Pure Encapsulations NeuroPure
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Designs For Health PaleoCleanse Plus™
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Pure Encapsulations Quercetin
Pure Encapsulations Quercetin
Metagenics Quercetin 500
Vitabase Quercetin Plus
Designs For Health Quercetin-Ascorbate
Douglas Laboratories Quercetin-Bromelain Complex
Thorne Quercetin Complex Quercenase
Designs For Health Quercetin + Nettles
Thorne Quercetin Phytosome
Pure Encapsulations Quercetin UltraSorb
Thorne ResveraCel
Designs For Health Resveratrol Supreme
Designs For Health Senolytic Synergy
Metagenics Sinuplex®
Designs For Health Stellar C™
Vitabase Super Antioxidant Formula
Pure Encapsulations Th2 Modulator
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Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories Ultra Preventive® X
Douglas Laboratories Ultra Protein Green
Metagenics UltraInflamX Plus 360°® Chocolate/Orange
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
Metagenics UltraInflamX Plus 360° Pineapple/Banana
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Pure Encapsulations Uric Acid Formula
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Integrative Therapeutics Vitamin C with Quercetin