Evidence supporting the use of: Ribose-l-cysteine
For the health condition: Free Radical Damage
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Ribose-l-cysteine is a synthetic compound designed to efficiently deliver cysteine, a key precursor for the endogenous antioxidant glutathione. Free radical damage, also known as oxidative stress, is implicated in a wide range of diseases and aging-related changes. Ribose-l-cysteine has been studied for its potential to boost glutathione levels more effectively than dietary cysteine or N-acetylcysteine (NAC), which can be limited by poor bioavailability or side effects.
Preclinical studies (in vitro and animal models) have shown that ribose-l-cysteine supplementation increases glutathione synthesis, enhances antioxidant defenses, and reduces markers of oxidative stress. For example, research published in peer-reviewed journals indicates that ribose-l-cysteine can decrease lipid peroxidation and DNA damage caused by free radicals in animal models. Additionally, some studies suggest it may offer protection in models of liver toxicity, cardiovascular stress, and diabetic complications.
However, human studies are limited. While there is a strong biochemical rationale and a growing body of preclinical data supporting its use for protecting against free radical damage, there is not yet robust clinical trial evidence in humans. Thus, ribose-l-cysteine is best described as having scientific support at the preclinical stage, with moderate evidence (level 3/5) for use against free radical damage based on current research.
Other ingredients used for Free Radical Damage
7-hydroxymatairesinol (HMR)acai berry
acetyl l-carnitine
alpha-carotene
alpha-glycosyl isoquercitrin
amino acids
anthocyanins
apricot
ascorbyl palmitate
astaxanthin
astragalus
basil
berry flavor
beta-carotene
beta-tocopherol
bilberry
black currant
black garlic
black tea
blackberry
blueberry
broccoli
brussel sprouts
caffeine
camu camu
catalase
catechins
caterpillar mushroom
cauliflower
chokeberry
chrysin
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
cryptoxanthin
turmeric
delta-tocopherol
epigallocatechin gallate (EGCG)
fish protein
flavonols
fruit blend (proprietary)
ginseng
grape
green tea
greens blend (proprietary)
guarana
hesperetin
hesperidin
HMR lignan
l-carnosine
l-cysteine
l-glutathione
l-glycine
lentinula edodes mycelia
lutein
matcha
melatonin
mixed carotenoids
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
oyster mushroom
phenolic acids
phospholipids
pine bark
pyrroloquinoline disodium salt
quercetin
raspberry
reishi mushroom
resveratrol
selenium
spirulina
strawberry
ubiquinol
vegetable blend (proprietary)
vitamin C
vitamin E
whey protein
zinc
papaya
bee pollen
lingzhi
ferulic acid
cistanche
ganoderma
royal jelly
polyphenols
fulvic acid
wheat germ
goji berry
algae
cocoa
1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose
3,3'-dihydroxy-B-carotene-4,4'-dione
3-Isomangostin
5,7-Dimethoxyflavone
7,4-Dimethoxyflavone
Amethoflavone
Ankaflavin
Apigenin
Aronia melanocarpa
Auricularia
Autumn Olive
Antirrhinin
Avocado
Amentoflavone
Acacetin
Allophycocyanin
Alpha-Lipoic Acid
Ascorbigen
Astragaloside
anthocyanidins
Algal protein
Acer Truncatum bunge
anthocyanosides
Argan nut oil
Apocarotenal
Apocynin
Arctiin
Arjunolic acid
Beta-hydroxybutyrate
beta-zeacarotene
Brassica
Bok Choy
Baccosides
BHT (Butylated Hydroxytoluene)
Benfotiamine
Basidiomycota
Betanin
berry
Brazil nut
boysenberry
BHA (butylated hydroxyanisole)
Bioflavonoids
bacoside
Baicalin
Caffeic Acid
Camellia sinensis
Carnosine
Chebulic acid
Cashew
Cichoric acid
Chocolate
Capsorubin
Carnosol
Cupric ascorbate
C-Phycocyanin
Carotene (unspecified)
Chebulinic acid
Crocetin
Canthaxanthin
Crypthecodinium
Capsanthin
Carnosic acid
Dunaliella salina
Dismutase
Delphinidin
Dunaliella
Dehydroascorbic acid
Dumontiaceae
Desoxyrhaponticin
Dragon Fruit
Dibenzo-alpha pyrones
Dihydrolipoic Acid
Diosmetin
epicatechin
Ellagic Acid
Ergothioneine
Emblicanin
Erythorbic acid
Ethylgallate
Eriodictyol
Ecklonia
Flavonones
walnut
Other health conditions supported by Ribose-l-cysteine
Cardiovascular DiseaseDiabetes
Free Radical Damage
Inflammation
Liver Detoxification