Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Royal jelly is sometimes used as a supplement to support the body against free radical damage, largely due to its antioxidant properties. Scientific studies have shown that royal jelly contains a variety of bioactive compounds, including proteins, peptides, and polyphenols, that can scavenge free radicals and may reduce oxidative stress in cells. In vitro (test tube) and animal studies have demonstrated that royal jelly can enhance the activity of antioxidant enzymes such as superoxide dismutase and glutathione peroxidase, and may reduce markers of oxidative stress.

For example, a 2012 study published in the journal Food and Chemical Toxicology found that royal jelly administration in rats exposed to oxidative toxins resulted in decreased lipid peroxidation and increased antioxidant enzyme activity. Other animal research supports these findings, suggesting a protective effect against chemically induced oxidative injuries.

However, while laboratory and animal data are promising, clinical studies in humans are limited and often of small scale. Some small trials have suggested minor improvements in oxidative stress markers among people who supplement with royal jelly, but larger and more rigorous human studies are needed to firmly establish its efficacy. Therefore, while there is scientific rationale and preliminary evidence for the use of royal jelly against free radical damage, the overall quality and quantity of human evidence is still modest, supporting a rating of 2 out of 5.

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