Evidence supporting the use of: Sesamolin
For the health condition: Free Radical Damage
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Sesamolin is a lignan compound found primarily in sesame seeds and sesame oil. Its use to support or treat free radical damage is primarily justified by scientific evidence, although the data is moderate and largely derived from preclinical studies. Several in vitro and animal studies have shown that sesamolin exhibits antioxidant properties, which means it can help neutralize free radicals and reduce oxidative stress. Mechanistically, sesamolin is believed to act as a free radical scavenger and may enhance the activity of endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase. For instance, studies published in peer-reviewed journals have demonstrated that sesamolin can decrease lipid peroxidation and protect biomolecules from oxidative damage in experimental models.
However, clinical trials in humans are limited, and much of the evidence supporting sesamolin’s antioxidant effects is based on laboratory and animal studies rather than large-scale human research. While these findings suggest a potential role for sesamolin in protecting against free radical damage, more rigorous clinical investigations are needed to establish its efficacy and safety in humans. Overall, sesamolin is scientifically recognized for its antioxidant activity, which supports its use against free radical damage, but the level of evidence is not yet robust enough for definitive clinical recommendations.
Other ingredients used for Free Radical Damage
1,2-di-galloyl-4,6hexahydroxydiphenoyl-D-glucose3,3'-dihydroxy-B-carotene-4,4'-dione
3-Isomangostin
5,7-Dimethoxyflavone
7,4-Dimethoxyflavone
7-hydroxymatairesinol (HMR)
Acacetin
Acai berry
Acer truncatum
Acetyl L-carnitine
Algae
Algal protein
Allophycocyanin
Alpha-carotene
alpha-glycosyl isoquercitrin
alpha-lipoic acid
amentoflavone
amethoflavone
amino acids
ankaflavin
anthocyanidins
anthocyanins
anthocyanosides
antirrhinin
apigenin
apocarotenal
apocynin
apricot
arctiin
argan nut oil
Arjunolic acid
Aronia melanocarpa
ascorbigen
ascorbyl palmitate
astaxanthin
astragaloside
astragalus
Auricularia
Autumn Olive
avocado
baccosides
bacoside
baicalin
Basidiomycota
basil
bee pollen
benfotiamine
berry
beta-carotene
beta-hydroxybutyrate
beta-tocopherol
beta-zeacarotene
betanin
BHA (butylated hydroxyanisole)
BHT (butylated hydroxytoluene)
bilberry
bioflavonoids
black currant
black garlic
black tea
blackberry
blueberry
bok choy
boysenberry
Brassica
Brazil nut
broccoli
Brussel sprouts
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
camu camu
canthaxanthin
capsanthin
capsorubin
carnosic acid
Carnosine
carnosol
carotene (unspecified)
cashew
catalase
catechins
caterpillar mushroom
cauliflower
chebulic acid
chebulinic acid
chocolate
chokeberry
chrysin
cichoric acid
cistanche
cocoa
coconut milk
coenzyme Q10 (CoQ10)
coffee fruit
crocetin
Crypthecodinium
cryptoxanthin
cupric ascorbate
dehydroascorbic acid
delphinidin
delta-tocopherol
desoxyrhaponticin
dibenzo-alpha pyrones
dihydrolipoic acid
diosmetin
dismutase
dragon fruit
Dumontiaceae
Dunaliella
Dunaliella salina
Ecklonia
ellagic acid
emblicanin
epicatechin
epigallocatechin gallate (EGCG)
ergothioneine
eriodictyol
erythorbic acid
ethylgallate
fatty acids
ferulic acid
fish protein
flavanones
flavans
flavin mononucleotide
flavoglycosides
flavones
flavonols
flavonones
fruit blend (proprietary)
fucoidan
fulvic acid
furanosterols
Gac
gamma-carotene
gamma-glutamylcysteine
ganoderma
Garcinone C
Garcinone E
ginseng
Ginsenosides
Glucan peptides
Glutathione
goji berry
grape
green tea
greens blend (proprietary)
guarana
Haematococcus pluvialis
hesperetin
hesperidin
HMR lignan
honeybush
hydroxycinnamic acid
hydroxyphenylethanols
hydroxytyrosol
Idebenone
isoascorbate
isovitexin
Jaboticaba
Kaempferol
kucha tea
L-carnosine
L-cysteine
L-glutathione
L-glycine
Lentinula edodes mycelia
Leucodelphinidin
lingzhi
lipids
lutein
Lycium
macadamia
malvidin
mangiferin
mangostanol
mangostene xanthone
Matcha
Mate
Melatonin
Methoxylated flavones
Methylselenocysteine
Mineral ascorbate
mixed carotenoids
Myricitrin
N-acetyl-cysteine (NAC)
N-Caffeoyldopamine
Neoandrographolides
Neoxanthin
nicotinamide riboside
Oligomeric proanthocyanidins
omega-3 fatty acids
oyster mushroom
papaya
Pecan
Pentacyclic triterpenoids
Pentose phosphate
phenolic compounds
Phosphate ascorbate
phospholipids
Phthalides
Phycocyanin
Phytoene
Phytofluene
Phytoplankton
pine bark
Plankton
Pleurotus eryngii
polymethoxylated flavones
polyphenols
polyporous mushroom
proanthocyanidins
procyanidin
procyanidol
propyl gallate
punicalagins
punicosides
Pycnogenol
pyrroloquinoline disodium salt
pyrroloquinoline quinone
quercetin
raspberry
reishi mushroom
resveratrol
rhammetin
Ribose-l-cysteine
robusta coffee
Rooibos
rosmarinic acid
royal jelly
Salidroside
Schisandrins
Scopoletin
selenium
Sesamolin
Shilajit
Silychristin
spirulina
Squalene
strawberry
Tangeretin
Taxifolin
Theaflavin
Tiliroside
Tremella
Trigalloyl glucose
turmeric
Tyrosol
ubiquinol
Uncaria
Vanillin
vegetable blend (proprietary)
Vestitol
vitamin C
vitamin E
Walnut
wheat germ
Whey protein
White Tea
Withanolides
Xanthone
Xanthophyll
Xylaria nigripes
Yumberry
Zinc
Other health conditions supported by Sesamolin
Cholesterol (high)Diabetes
Free Radical Damage
Inflammation
Metabolic Syndrome
Triglycerides (high)