Evidence supporting the use of: Alantolactone
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alantolactone is a naturally occurring sesquiterpene lactone found in the roots of Inula helenium (elecampane) and other plant species. There is emerging scientific interest in its potential antifungal activity, primarily based on in vitro studies. Several laboratory investigations have demonstrated that alantolactone exhibits inhibitory effects against various fungal pathogens, including Candida albicans and Aspergillus species. The proposed mechanisms of action involve disruption of fungal cell membranes, induction of reactive oxygen species (ROS), and interference with biofilm formation.

Despite these promising results, the evidence remains preliminary. Most studies to date have been conducted in vitro (test tubes or petri dishes), and there is a lack of robust in vivo data (animal or human studies) demonstrating efficacy or safety for the treatment of fungal infections. There are no clinical trials or high-quality human studies available to validate its use as an antifungal agent in medical practice. While traditional herbal medicine systems have used elecampane for various conditions, including respiratory complaints, there is little documented traditional use specifically targeting fungal infections.

In summary, while there is scientific interest and some laboratory evidence supporting the antifungal potential of alantolactone, the current level of evidence is limited and insufficient to recommend it for clinical use against fungal infections at this time.

More about Alantolactone
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Products containing Alantolactone

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