Evidence supporting the use of: Allyl Sulfide
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Allyl sulfide is a sulfur-containing compound most commonly found in garlic (Allium sativum) and related plants. Its antifungal properties have been investigated in several in vitro studies. Research indicates that allyl sulfides, such as diallyl sulfide and diallyl disulfide, can inhibit the growth of various fungal pathogens, including Candida albicans and Aspergillus species. The proposed mechanism involves disruption of cell membrane integrity and interference with the metabolism of the fungi. However, the bulk of this evidence comes from laboratory (test tube) and some animal studies, rather than human clinical trials. Traditional medicine, especially in cultures that use garlic therapeutically, has used garlic extracts for infections broadly, but not specifically targeting allyl sulfide as the active agent.

To date, there are no robust clinical trials clearly demonstrating the efficacy of isolated allyl sulfide compounds in treating or preventing fungal infections in humans. Most human-focused research uses whole garlic extracts, which contain multiple bioactive compounds. Therefore, while there is a scientific rationale and laboratory evidence supporting antifungal activity, clinical evidence in humans is limited, justifying a moderate-low evidence score.

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