Evidence supporting the use of: Alpha-terpineol
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-terpineol is a naturally occurring monoterpene alcohol found in many essential oils, such as tea tree, pine, and eucalyptus oils. Scientific studies have demonstrated that alpha-terpineol possesses antifungal activity in vitro against several pathogenic fungi, including Candida albicans and dermatophytes. For instance, research published in peer-reviewed journals has shown that alpha-terpineol can disrupt fungal cell membranes, leading to cell death. The proposed mechanisms include increased membrane permeability and interference with ergosterol biosynthesis, which is crucial for fungal cell membrane integrity.

However, most of the evidence for alpha-terpineol’s antifungal effects comes from laboratory (in vitro) studies, not from clinical trials in humans. There is a lack of robust, high-quality clinical data demonstrating its efficacy and safety when used to treat or support fungal infections in humans. Furthermore, it is often a component of essential oils rather than used as an isolated compound in medical practice. Therefore, while there is scientific rationale and preliminary laboratory evidence supporting its antifungal potential, clinical validation is limited, leading to a moderate evidence rating.

In summary, alpha-terpineol shows promise as an antifungal agent based on scientific studies in the laboratory, but more clinical research is necessary before it can be confidently recommended for the treatment or support of fungal infections in humans.

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Products containing Alpha-terpineol

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