Evidence supporting the use of: Australian Sandalwood
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Australian Sandalwood (Santalum spicatum) has garnered some scientific interest for its antifungal properties, particularly due to its essential oil, which contains active constituents such as alpha- and beta-santalol. Several in vitro studies have demonstrated that Australian Sandalwood oil exhibits activity against common fungal pathogens, including Trichophyton rubrum and Candida albicans. For example, a study published in the journal Phytotherapy Research (2004) reported inhibitory effects of Santalum spicatum oil against dermatophytes and yeasts. However, most of the available evidence is limited to laboratory (in vitro) investigations, and there is a lack of robust clinical trials in humans to confirm efficacy or safety for the treatment of fungal infections.

Traditionally, Australian Sandalwood has been used by Indigenous Australians for various medicinal purposes, but direct historical documentation specifically referencing its use for fungal infections is sparse. Its application as a topical antimicrobial agent is more recent and driven by scientific exploration rather than established ethnobotanical practice. Overall, while laboratory studies suggest potential antifungal effects, the current level of evidence is modest, warranting a rating of 2 out of 5, and further clinical research is needed to validate its use for treating fungal infections in humans.

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