Evidence supporting the use of: Benzoic acid
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Benzoic acid is recognized for its antifungal properties and has been historically used in combination with salicylic acid (Whitfield's ointment) to treat superficial fungal infections of the skin, such as tinea pedis (athlete's foot) and tinea corporis (ringworm). The scientific basis for its use is rooted in its ability to inhibit the growth of certain fungi by acidifying the environment, thereby disrupting fungal cell metabolism and growth. Several in vitro studies have demonstrated that benzoic acid can suppress the growth of dermatophytes and some yeast species at appropriate concentrations.

Clinical support for its efficacy comes from its inclusion in topical formulations for dermatophytosis and its endorsement in some dermatology guidelines as a reasonable option, especially in resource-limited settings. However, benzoic acid is generally considered less effective than modern antifungal agents like azoles and allylamines, and thus is not typically a first-line treatment in contemporary practice. Despite this, its low cost, general safety profile, and historical effectiveness provide scientific validation for its use, particularly for mild or superficial infections.

Overall, the evidence for benzoic acid's antifungal efficacy is moderate (rated 3/5), largely based on laboratory findings, clinical experience, and its continued presence in some pharmacopeias, rather than large, modern randomized controlled trials.

More about Benzoic acid
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