Evidence supporting the use of: Black Nightshade
For the health condition: Fungal Infections

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Black Nightshade (Solanum nigrum) has a history of use in traditional medicine systems, particularly in Ayurveda and various folk medicines across Asia and Africa, for a range of ailments, including skin diseases and infections. Its application for fungal infections is primarily based on its traditional use as a topical agent for skin conditions, some of which may have been of fungal origin. Ethnobotanical records cite preparations of Black Nightshade leaves and berries being applied to ringworm and other dermatological issues, which are sometimes caused by fungi.

On the scientific front, there is limited but notable research indicating that extracts of Solanum nigrum possess some antifungal activity in vitro. Studies have reported inhibitory effects against certain fungal strains, such as Aspergillus and Candida species, but these findings are mostly preliminary and have not been extensively validated in animal models or clinical trials. The active compounds potentially responsible include steroidal alkaloids and glycosides, which may disrupt fungal cell membranes.

However, the overall body of scientific evidence remains sparse, and there are no well-established clinical studies confirming Black Nightshade’s efficacy or safety for treating fungal infections in humans. Therefore, while its use is grounded in tradition and supported by some laboratory data, it lacks robust scientific validation.

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