Black seed oil, derived from Nigella sativa, has a long history in traditional medicine systems for treating various ailments, including infections. In recent years, several laboratory studies have investigated its antifungal properties. The main active compound, thymoquinone, has demonstrated inhibitory effects against a range of fungal species, particularly Candida albicans, in vitro (test tube) studies. Some research has reported comparable antifungal activity to standard antifungal drugs in these controlled environments.

However, clinical evidence in humans remains limited. There are a few small-scale human studies and case reports suggesting benefit, but these are not sufficient to establish efficacy or safety for routine use in treating fungal infections. Most available data are from animal models or in vitro experiments, which do not always translate to effectiveness in humans.

In summary, while there is a scientific basis for the antifungal properties of black seed oil based on laboratory research, high-quality clinical trials are lacking. Its use for fungal infections is supported by some promising early data, but the overall strength of evidence is low at this time.