Evidence supporting the use of: Caryophyllene
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Caryophyllene, particularly β-caryophyllene, is a natural bicyclic sesquiterpene found in various essential oils, including those of clove, black pepper, and cannabis. There is some scientific evidence suggesting that β-caryophyllene possesses antifungal properties. Several in vitro studies have demonstrated that β-caryophyllene and essential oils rich in this compound can inhibit the growth of certain fungal species, such as Candida albicans and Aspergillus niger. For example, a study published in Phytotherapy Research (2016) showed moderate antifungal activity of β-caryophyllene against Candida species, and other research has supported its role in disrupting fungal cell membranes.

However, the bulk of research remains preliminary and largely laboratory-based, with few if any clinical trials in humans. The mechanism of action is thought to involve disruption of the fungal cell membrane and interference with ergosterol synthesis, but these effects have yet to be confirmed in clinical settings. While β-caryophyllene is used traditionally in some herbal medicine systems, its use specifically for fungal infections is not prominent in ethnomedicine literature. Overall, while scientific studies support the potential antifungal effects of caryophyllene, the evidence is limited and not robust enough to warrant strong clinical recommendations. Thus, its use for fungal infections is supported by some scientific research, but the overall evidence is weak to moderate (rated 2/5).

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