Evidence supporting the use of: Caryophyllene
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Caryophyllene, particularly β-caryophyllene, is a natural bicyclic sesquiterpene found in various essential oils, including those of clove, black pepper, and cannabis. There is some scientific evidence suggesting that β-caryophyllene possesses antifungal properties. Several in vitro studies have demonstrated that β-caryophyllene and essential oils rich in this compound can inhibit the growth of certain fungal species, such as Candida albicans and Aspergillus niger. For example, a study published in Phytotherapy Research (2016) showed moderate antifungal activity of β-caryophyllene against Candida species, and other research has supported its role in disrupting fungal cell membranes.

However, the bulk of research remains preliminary and largely laboratory-based, with few if any clinical trials in humans. The mechanism of action is thought to involve disruption of the fungal cell membrane and interference with ergosterol synthesis, but these effects have yet to be confirmed in clinical settings. While β-caryophyllene is used traditionally in some herbal medicine systems, its use specifically for fungal infections is not prominent in ethnomedicine literature. Overall, while scientific studies support the potential antifungal effects of caryophyllene, the evidence is limited and not robust enough to warrant strong clinical recommendations. Thus, its use for fungal infections is supported by some scientific research, but the overall evidence is weak to moderate (rated 2/5).

More about caryophyllene
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Other ingredients used for Fungal Infections

10-Undecenoic Acid
3-Phenyllactic Acid
Agarikon Mushroom
Ajoene
Ajuga
Alantolactone
Allicin
Allium tuberosum
Allyl isothiocyanate
Allyl sulfide
Aloe vera
alpha-pinene
alpha-terpineol
Ampelopsis
anamu
Ardisia
babchi
Baphicacanthus cusia
barberry
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basil
bee hive
bee propolis
benzyl isothiocyanate
beta-pinene
bisabolene
black nightshade
black walnut
borneol
Brazilian peppertree
Caesalpinia crista
cajuput
Calendula
camphor oil
caprylic acid
carvacrol
caryophyllene
Centipeda
chalcone
chamomile
Cinnamomum
cinnamon
citral
citronella
coconut oil
commiphora
copaiba oil
curry leaf
Dianthus
eucalyptus
eugenol
Euphorbia
gamma-terpinene
garlic
geranial
geraniol
geranium
Glechoma hederacea
glyceryl caprylate caprate
glyceryl monolaurate
Gnaphalium
goldenseal
green tea
Hedyotis
henna
Herb Robert
Houttuynia
Indian fagonia
jojoba oil
Kefir
Labdanum
Lactoperoxidase
Laggera pterodonta
Lantana camara
lauric acid
Lebbek
lemongrass
Leptospermum scoparium
lichen
linalool
Litsea
liverwort
lodhtree
Macaranga indica
Mahonia
mangostin
marigold
Marking Nut Tree
melaleuca alternifolia
Melia
Menthol oil
Monolaurin
Morinda
Mountain Pepper
Mustard
Naphthoquinones
Neem tree
nut grass
Onosma bracteatum
oregano
oregon grape
oriental arborvitae
Oroxylum indicum
pau d'arco
Pentacyclic triterpenoids
phenolic compounds
phlorotannins
Plectranthus amboinicus
Plumbago zeylanica
Polygodial
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Propolis
rosemary
rue
sage
Salvia
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Sapindus mukorossi
schizonepeta
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Soapberry
Sophora
Stereospermum
Storax
Sumac
Tea Tree Oil
Terpinen-4-ol
Terpinolene
Thaumatococcus daniellii
Thiosulfinate
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Thymol
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Products containing caryophyllene

We currently have no products on Vitabase that contain this ingredient.