Evidence supporting the use of: Chalcone
For the health condition: Fungal Infections
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Chalcone and its derivatives have been studied for their antifungal properties in vitro and in some preclinical models. Chalcones are naturally occurring compounds found in many plants and are precursors to flavonoids. Several laboratory studies have reported that certain chalcone derivatives can inhibit the growth of various fungal species, including Candida albicans, Aspergillus spp., and Trichophyton spp. The proposed mechanisms include disruption of fungal cell wall synthesis, inhibition of efflux pumps, and interference with mitochondrial function. However, most evidence is limited to cell cultures and animal models, with very few studies progressing to clinical trials in humans. There is no established use of chalcone as a standard antifungal treatment in clinical practice, and dosing, safety, and efficacy in humans remain unclear. In summary, while there is promising preclinical evidence supporting the antifungal potential of chalcone, robust clinical evidence is lacking, and its use for fungal infections is not currently supported by strong scientific consensus.
Other ingredients used for Fungal Infections
10-Undecenoic Acid3-Phenyllactic Acid
Agarikon Mushroom
Ajoene
Ajuga
Alantolactone
Allicin
Allium tuberosum
Allyl isothiocyanate
Allyl sulfide
Aloe vera
alpha-pinene
alpha-terpineol
Ampelopsis
anamu
Ardisia
babchi
Baphicacanthus cusia
barberry
Barleria
basil
bee hive
bee propolis
benzyl isothiocyanate
beta-pinene
bisabolene
black nightshade
black walnut
borneol
Brazilian peppertree
Caesalpinia crista
cajuput
Calendula
camphor oil
caprylic acid
carvacrol
caryophyllene
Centipeda
chalcone
chamomile
Cinnamomum
cinnamon
citral
citronella
coconut oil
commiphora
copaiba oil
curry leaf
Dianthus
eucalyptus
eugenol
Euphorbia
gamma-terpinene
garlic
geranial
geraniol
geranium
Glechoma hederacea
glyceryl caprylate caprate
glyceryl monolaurate
Gnaphalium
goldenseal
green tea
Hedyotis
henna
Herb Robert
Houttuynia
Indian fagonia
jojoba oil
Kefir
Labdanum
Lactoperoxidase
Laggera pterodonta
Lantana camara
lauric acid
Lebbek
lemongrass
Leptospermum scoparium
lichen
linalool
Litsea
liverwort
lodhtree
Macaranga indica
Mahonia
mangostin
marigold
Marking Nut Tree
melaleuca alternifolia
Melia
Menthol oil
Monolaurin
Morinda
Mountain Pepper
Mustard
Naphthoquinones
Neem tree
nut grass
Onosma bracteatum
oregano
oregon grape
oriental arborvitae
Oroxylum indicum
pau d'arco
Pentacyclic triterpenoids
phenolic compounds
phlorotannins
Plectranthus amboinicus
Plumbago zeylanica
Polygodial
polyphenols
Propolis
rosemary
rue
sage
Salvia
Sandalwood
Sapindus mukorossi
schizonepeta
Self-Heal
Soapberry
Sophora
Stereospermum
Storax
Sumac
Tea Tree Oil
Terpinen-4-ol
Terpinolene
Thaumatococcus daniellii
Thiosulfinate
Thuja
Thymol
Tulbaghia
turmeric
Undecylenic acid
Violet
Water Pepper
Winter Savory
Wrightia tinctoria
zanthoxylum
Zingiberene
Other health conditions supported by chalcone
Antibiotics (alternatives to)Cancer (natural therapy for)
Cancer (prevention)
Diabetes
Fungal Infections
Inflammation