Evidence supporting the use of: Glyceryl caprylate caprate
For the health condition: Fungal Infections
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Glyceryl caprylate caprate is a mixture of mono- and diglycerides derived from caprylic and capric acids, which are medium-chain fatty acids (MCFAs). These compounds are commonly used in cosmetic and personal care formulations as emulsifiers and co-emulsifiers. Scientific evidence suggests that glyceryl caprylate, as well as its related MCFAs, possess mild antimicrobial properties, including activity against certain fungal species such as Malassezia and Candida. The antifungal effects are attributed to the ability of medium-chain fatty acids to disrupt the lipid membranes of fungi, thereby inhibiting their growth or viability.
However, the evidence base is limited primarily to in vitro studies and data extrapolated from the action of pure caprylic and capric acids, rather than the glyceryl esters specifically. There are few, if any, clinical studies directly assessing the efficacy of glyceryl caprylate caprate as a primary or adjunctive treatment for fungal infections in humans. In practice, its main application is as a preservative booster in topical products, helping to inhibit microbial contamination. While there is a scientific rationale for its inclusion in antifungal formulations due to its mild activity, its potency is considerably lower than that of pharmacological antifungals. Therefore, while there is some scientific support for its antifungal properties, the overall quality and quantity of evidence is modest and does not support standalone therapeutic use.
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Allium tuberosum
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Aloe vera
alpha-pinene
alpha-terpineol
Ampelopsis
anamu
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babchi
Baphicacanthus cusia
barberry
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basil
bee hive
bee propolis
benzyl isothiocyanate
beta-pinene
bisabolene
black nightshade
black walnut
borneol
Brazilian peppertree
Caesalpinia crista
cajuput
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camphor oil
caprylic acid
carvacrol
caryophyllene
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chalcone
chamomile
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cinnamon
citral
citronella
coconut oil
commiphora
copaiba oil
curry leaf
Dianthus
eucalyptus
eugenol
Euphorbia
gamma-terpinene
garlic
geranial
geraniol
geranium
Glechoma hederacea
glyceryl caprylate caprate
glyceryl monolaurate
Gnaphalium
goldenseal
green tea
Hedyotis
henna
Herb Robert
Houttuynia
Indian fagonia
jojoba oil
Kefir
Labdanum
Lactoperoxidase
Laggera pterodonta
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lauric acid
Lebbek
lemongrass
Leptospermum scoparium
lichen
linalool
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liverwort
lodhtree
Macaranga indica
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mangostin
marigold
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melaleuca alternifolia
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Monolaurin
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Mountain Pepper
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Naphthoquinones
Neem tree
nut grass
Onosma bracteatum
oregano
oregon grape
oriental arborvitae
Oroxylum indicum
pau d'arco
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phenolic compounds
phlorotannins
Plectranthus amboinicus
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Polygodial
polyphenols
Propolis
rosemary
rue
sage
Salvia
Sandalwood
Sapindus mukorossi
schizonepeta
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Sophora
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turmeric
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zanthoxylum
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Other health conditions supported by glyceryl caprylate caprate
Fungal InfectionsInfection (bacterial)
Skin (infections)
