Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactoperoxidase is an enzyme naturally present in milk and other secretions, and its antimicrobial activity has been recognized for decades. It catalyzes the oxidation of thiocyanate ions (SCN-) in the presence of hydrogen peroxide to generate hypothiocyanite (OSCN-), a compound with broad-spectrum microbicidal properties. Several in vitro studies have demonstrated that lactoperoxidase systems can inhibit the growth of a variety of fungi, including Candida albicans and other opportunistic pathogens. The mechanism is thought to involve oxidative damage to fungal cell membranes and interruption of critical metabolic pathways.

Despite these promising laboratory findings, clinical evidence supporting the use of lactoperoxidase-containing products for the treatment or prevention of fungal infections in humans is limited. Most studies are preclinical or use oral care products where lactoperoxidase is included as part of a broader antimicrobial system. Some mouthwashes and toothpaste formulations leverage lactoperoxidase for its antifungal and antibacterial effects, especially in immunocompromised patients susceptible to oral candidiasis. However, robust, large-scale clinical trials directly evaluating its efficacy against fungal infections are lacking.

In summary, while there is scientific rationale and some laboratory evidence to support the antifungal potential of lactoperoxidase, clinical validation remains insufficient. Therefore, the strength of evidence is moderate at best, justifying a rating of 2 out of 5.

More about lactoperoxidase
More about Fungal Infections

Other ingredients used for Fungal Infections

Other health conditions supported by lactoperoxidase

Products containing lactoperoxidase

Metagenics Probioplex® Intensive Care Powder