Neem (Azadirachta indica) has a long history of traditional use in Ayurvedic and folk medicine for treating various skin conditions, including fungal infections. In recent decades, scientific research has provided support for its antifungal properties. Laboratory studies have shown that extracts from neem leaves, bark, and oil possess activity against a range of pathogenic fungi, including Trichophyton, Microsporum, and Candida species. The antifungal effects are thought to be due to compounds such as nimbidin, nimbin, and gedunin, which disrupt fungal cell membranes and inhibit growth.

Several in vitro studies (test tube studies) have demonstrated neem's effectiveness against dermatophytes (fungi that cause skin infections like ringworm and athlete’s foot). Some small clinical studies and case reports from India and other countries also suggest benefit when neem extracts or oil are applied topically for managing superficial fungal infections. However, robust, large-scale clinical trials are lacking, and most evidence comes from laboratory or small-scale human studies.

In summary, neem's use for fungal infections is supported by both traditional practice and emerging scientific evidence, particularly from laboratory research. While promising, more high-quality clinical studies are needed to fully validate neem’s efficacy and safety for this indication.