Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Neem tree (Azadirachta indica) has been traditionally used in Ayurvedic and folk medicine for a variety of skin ailments, including fungal infections. Its use for fungal infections is supported by both historical practice and modern scientific research. Laboratory studies have shown that neem extracts possess significant antifungal activity against common pathogenic fungi such as Candida albicans, Aspergillus species, and dermatophytes (the fungi responsible for ringworm and athlete’s foot). The antifungal properties of neem are attributed primarily to compounds such as nimbidin, nimbin, and gedunin, which disrupt fungal cell membranes and inhibit their growth.

A number of in vitro studies confirm these effects, demonstrating that neem extracts can inhibit spore germination and hyphal growth. Some animal studies have also shown reduction in fungal load with neem treatment. However, high-quality human clinical trials are limited, and most evidence to date comes from laboratory and animal models, or from traditional use. Neem is commonly used in topical formulations (creams, oils, soaps) for skin conditions, including fungal infections, in many parts of Asia.

In summary, neem’s use for fungal infections is justified by both historical tradition and a moderate level of scientific evidence, especially laboratory studies. However, more rigorous clinical trials are needed to rate the evidence higher and to standardize effective formulations and dosages.

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