Evidence supporting the use of: Origanum (unspecified)
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Origanum species, particularly Origanum vulgare (oregano), have a long history of use in traditional medicine for a variety of ailments, including infections. In recent years, scientific research has investigated the antifungal properties of oregano and its constituents, especially carvacrol and thymol. In vitro studies have demonstrated that oregano essential oil exhibits significant activity against a range of fungal pathogens, including Candida albicans, Aspergillus species, and dermatophytes. The proposed mechanisms involve disruption of fungal cell membranes and inhibition of biofilm formation. Some animal studies have supported these findings, showing reduced fungal burden with oregano oil treatment. However, clinical evidence in humans is limited, consisting mainly of case reports and small pilot studies; robust randomized controlled trials are lacking. The majority of the scientific validation comes from laboratory and preclinical studies rather than large-scale human trials. Thus, while there is scientific basis for the antifungal activity of Origanum, especially in topical or adjunctive applications, the strength of evidence for its use in treating fungal infections in humans is moderate and not conclusive. Caution is advised with internal use due to potential toxicity at high doses.

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