Evidence supporting the use of: Pentacyclic triterpenoids
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pentacyclic triterpenoids are a diverse class of plant-derived compounds found in various medicinal herbs, including betulinic acid, oleanolic acid, and ursolic acid. There is some scientific evidence supporting their antifungal properties. In vitro studies have shown that several pentacyclic triterpenoids exhibit inhibitory effects against a range of pathogenic fungi, such as Candida albicans, Aspergillus spp., and dermatophytes. The proposed mechanisms include disruption of fungal cell membranes, inhibition of ergosterol synthesis, and interference with cell wall integrity. For example, research published in peer-reviewed journals like Phytomedicine and Fitoterapia has documented the antifungal efficacy of oleanolic acid and ursolic acid, with minimal inhibitory concentrations (MICs) in the low micromolar range for some species.

However, most of the available evidence is preclinical and limited to laboratory (in vitro) studies or, less commonly, animal models. There is a lack of robust clinical trials in humans evaluating the efficacy of pentacyclic triterpenoids as antifungal agents. As such, while the scientific rationale exists and laboratory results are promising, the evidence base is not strong enough to fully validate the use of these compounds for treating fungal infections in clinical practice. Further research, especially human clinical trials, is needed to confirm their safety and effectiveness.

More about Pentacyclic triterpenoids
More about Fungal Infections

Other ingredients used for Fungal Infections

10-Undecenoic Acid
3-Phenyllactic Acid
Agarikon Mushroom
Ajoene
Ajuga
Alantolactone
Allicin
Allium tuberosum
Allyl isothiocyanate
Allyl sulfide
Aloe vera
alpha-pinene
alpha-terpineol
Ampelopsis
anamu
Ardisia
babchi
Baphicacanthus cusia
barberry
Barleria
basil
bee hive
bee propolis
benzyl isothiocyanate
beta-pinene
bisabolene
black nightshade
black walnut
borneol
Brazilian peppertree
Caesalpinia crista
cajuput
Calendula
camphor oil
caprylic acid
carvacrol
caryophyllene
Centipeda
chalcone
chamomile
Cinnamomum
cinnamon
citral
citronella
coconut oil
commiphora
copaiba oil
curry leaf
Dianthus
eucalyptus
eugenol
Euphorbia
gamma-terpinene
garlic
geranial
geraniol
geranium
Glechoma hederacea
glyceryl caprylate caprate
glyceryl monolaurate
Gnaphalium
goldenseal
green tea
Hedyotis
henna
Herb Robert
Houttuynia
Indian fagonia
jojoba oil
Kefir
Labdanum
Lactoperoxidase
Laggera pterodonta
Lantana camara
lauric acid
Lebbek
lemongrass
Leptospermum scoparium
lichen
linalool
Litsea
liverwort
lodhtree
Macaranga indica
Mahonia
mangostin
marigold
Marking Nut Tree
melaleuca alternifolia
Melia
Menthol oil
Monolaurin
Morinda
Mountain Pepper
Mustard
Naphthoquinones
Neem tree
nut grass
Onosma bracteatum
oregano
oregon grape
oriental arborvitae
Oroxylum indicum
pau d'arco
Pentacyclic triterpenoids
phenolic compounds
phlorotannins
Plectranthus amboinicus
Plumbago zeylanica
Polygodial
polyphenols
Propolis
rosemary
rue
sage
Salvia
Sandalwood
Sapindus mukorossi
schizonepeta
Self-Heal
Soapberry
Sophora
Stereospermum
Storax
Sumac
Tea Tree Oil
Terpinen-4-ol
Terpinolene
Thaumatococcus daniellii
Thiosulfinate
Thuja
Thymol
Tulbaghia
turmeric
Undecylenic acid
Violet
Water Pepper
Winter Savory
Wrightia tinctoria
zanthoxylum
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Products containing Pentacyclic triterpenoids

We currently have no products on Vitabase that contain this ingredient.