Evidence supporting the use of: Pentacyclic triterpenoids (unspecified)
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pentacyclic triterpenoids are a diverse class of plant-derived compounds found in various medicinal herbs, including betulinic acid, oleanolic acid, and ursolic acid. There is some scientific evidence supporting their antifungal properties. In vitro studies have shown that several pentacyclic triterpenoids exhibit inhibitory effects against a range of pathogenic fungi, such as Candida albicans, Aspergillus spp., and dermatophytes. The proposed mechanisms include disruption of fungal cell membranes, inhibition of ergosterol synthesis, and interference with cell wall integrity. For example, research published in peer-reviewed journals like Phytomedicine and Fitoterapia has documented the antifungal efficacy of oleanolic acid and ursolic acid, with minimal inhibitory concentrations (MICs) in the low micromolar range for some species.

However, most of the available evidence is preclinical and limited to laboratory (in vitro) studies or, less commonly, animal models. There is a lack of robust clinical trials in humans evaluating the efficacy of pentacyclic triterpenoids as antifungal agents. As such, while the scientific rationale exists and laboratory results are promising, the evidence base is not strong enough to fully validate the use of these compounds for treating fungal infections in clinical practice. Further research, especially human clinical trials, is needed to confirm their safety and effectiveness.

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