Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polyphenols are a diverse group of naturally occurring compounds found in plants, including flavonoids, phenolic acids, tannins, and lignans. Their use in supporting or treating fungal infections is primarily grounded in scientific research, though much of this evidence is preclinical (in vitro or animal studies) rather than clinical. Several polyphenols, such as those found in green tea (epigallocatechin gallate), curcumin (from turmeric), resveratrol (from grapes), and catechins, have demonstrated antifungal activity against a variety of pathogenic fungi including Candida albicans, Aspergillus spp., and dermatophytes, in laboratory settings. The mechanisms appear to involve disruption of fungal cell walls and membranes, inhibition of fungal enzymes, and interference with biofilm formation, which are all crucial for fungal survival and virulence.

However, while these effects are promising, robust human clinical trials assessing the efficacy and safety of polyphenols specifically for treating or preventing fungal infections are lacking. Most evidence comes from laboratory studies or animal models, which may not directly translate to human health outcomes. Furthermore, the bioavailability of polyphenols (how well they are absorbed and reach target tissues) can be quite low, which may limit their effectiveness in vivo. Thus, while there is a scientific basis for the antifungal potential of polyphenols, the current level of evidence supporting their use in clinical practice is limited, justifying a moderate evidence rating.

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