Evidence supporting the use of: Sulfur compounds (unspecified)
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Sulfur compounds have a long-standing history of use in the treatment of fungal infections, particularly in dermatology. Elemental sulfur and various sulfur-containing preparations (such as precipitated sulfur, sulfur ointments, and sulfide solutions) have been employed topically for centuries to treat conditions such as tinea versicolor, scabies, and other superficial fungal and parasitic infections. The antifungal action of sulfur is attributed to its keratolytic and antimicrobial properties, which disrupt the cell walls of fungi and inhibit their growth. Modern scientific studies confirm that sulfur exhibits fungistatic and fungicidal activities against a variety of dermatophytes and yeasts, although it is generally less potent than newer antifungal agents. Clinical guidelines continue to mention sulfur as an alternative, especially in resource-limited settings or for patients intolerant of modern antifungals. However, the evidence base is moderate: most data arise from historical usage, observational studies, and in vitro research rather than large randomized controlled trials. Overall, sulfur compounds remain a scientifically validated, albeit older, option for the topical management of certain superficial fungal infections.

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