Evidence supporting the use of: Thiosulfinate
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Thiosulfinates are a class of organosulfur compounds most notably found in garlic (Allium sativum) and onions, with allicin being the best-known thiosulfinate. Their use in supporting or treating fungal infections is justified by a moderate level of scientific evidence. Several in vitro studies have demonstrated that allicin and related thiosulfinates possess broad-spectrum antifungal activity, notably against Candida species, Aspergillus, and some dermatophytes. The mechanism of action is thought to involve the inhibition of fungal enzymes through the interaction with thiol groups, leading to cell membrane disruption and reduced fungal viability.

However, while laboratory and animal studies are promising, robust clinical evidence in humans is limited. Some small-scale clinical trials and case reports suggest benefits in treating superficial fungal infections (such as athlete’s foot and oral candidiasis), but large, well-controlled studies are lacking. Thiosulfinates are not generally recommended as first-line therapy in clinical guidelines, likely due to variability in bioavailability, formulation, and the lack of standardized dosing. Traditional medicine systems have used garlic extracts for various infections, but the scientific focus is specifically on thiosulfinates for their antifungal properties. Overall, thiosulfinates show promise as adjunctive agents or topical treatments, but more rigorous human trials are needed to establish efficacy and safety for the treatment of fungal infections.

More about Thiosulfinate
More about Fungal Infections

Other ingredients used for Fungal Infections

10-Undecenoic Acid
3-Phenyllactic Acid
Agarikon Mushroom
Ajoene
Ajuga
Alantolactone
Allicin
Allium tuberosum
Allyl isothiocyanate
Allyl sulfide
Aloe vera
alpha-pinene
alpha-terpineol
Ampelopsis
anamu
Ardisia
babchi
Baphicacanthus cusia
barberry
Barleria
basil
bee hive
bee propolis
benzyl isothiocyanate
beta-pinene
bisabolene
black nightshade
black walnut
borneol
Brazilian peppertree
Caesalpinia crista
cajuput
Calendula
camphor oil
caprylic acid
carvacrol
caryophyllene
Centipeda
chalcone
chamomile
Cinnamomum
cinnamon
citral
citronella
coconut oil
commiphora
copaiba oil
curry leaf
Dianthus
eucalyptus
eugenol
Euphorbia
gamma-terpinene
garlic
geranial
geraniol
geranium
Glechoma hederacea
glyceryl caprylate caprate
glyceryl monolaurate
Gnaphalium
goldenseal
green tea
Hedyotis
henna
Herb Robert
Houttuynia
Indian fagonia
jojoba oil
Kefir
Labdanum
Lactoperoxidase
Laggera pterodonta
Lantana camara
lauric acid
Lebbek
lemongrass
Leptospermum scoparium
lichen
linalool
Litsea
liverwort
lodhtree
Macaranga indica
Mahonia
mangostin
marigold
Marking Nut Tree
melaleuca alternifolia
Melia
Menthol oil
Monolaurin
Morinda
Mountain Pepper
Mustard
Naphthoquinones
Neem tree
nut grass
Onosma bracteatum
oregano
oregon grape
oriental arborvitae
Oroxylum indicum
pau d'arco
Pentacyclic triterpenoids
phenolic compounds
phlorotannins
Plectranthus amboinicus
Plumbago zeylanica
Polygodial
polyphenols
Propolis
rosemary
rue
sage
Salvia
Sandalwood
Sapindus mukorossi
schizonepeta
Self-Heal
Soapberry
Sophora
Stereospermum
Storax
Sumac
Tea Tree Oil
Terpinen-4-ol
Terpinolene
Thaumatococcus daniellii
Thiosulfinate
Thuja
Thymol
Tulbaghia
turmeric
Undecylenic acid
Violet
Water Pepper
Winter Savory
Wrightia tinctoria
zanthoxylum
Zingiberene

Products containing Thiosulfinate

We currently have no products on Vitabase that contain this ingredient.