Evidence supporting the use of: Thiosulfinate
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Thiosulfinates are a class of organosulfur compounds most notably found in garlic (Allium sativum) and onions, with allicin being the best-known thiosulfinate. Their use in supporting or treating fungal infections is justified by a moderate level of scientific evidence. Several in vitro studies have demonstrated that allicin and related thiosulfinates possess broad-spectrum antifungal activity, notably against Candida species, Aspergillus, and some dermatophytes. The mechanism of action is thought to involve the inhibition of fungal enzymes through the interaction with thiol groups, leading to cell membrane disruption and reduced fungal viability.

However, while laboratory and animal studies are promising, robust clinical evidence in humans is limited. Some small-scale clinical trials and case reports suggest benefits in treating superficial fungal infections (such as athlete’s foot and oral candidiasis), but large, well-controlled studies are lacking. Thiosulfinates are not generally recommended as first-line therapy in clinical guidelines, likely due to variability in bioavailability, formulation, and the lack of standardized dosing. Traditional medicine systems have used garlic extracts for various infections, but the scientific focus is specifically on thiosulfinates for their antifungal properties. Overall, thiosulfinates show promise as adjunctive agents or topical treatments, but more rigorous human trials are needed to establish efficacy and safety for the treatment of fungal infections.

More about Thiosulfinate
More about Fungal Infections

Other ingredients used for Fungal Infections

Ajoene
Aloe vera
alpha-pinene
barberry
basil
beta-pinene
bisabolol
black walnut
caprylic acid
chamomile
cinnamon
turmeric
goldenseal
green tea
lactoperoxidase
lauric acid
monolaurin
oregano
oregon grape
phenolic compounds
rosemary
sage
schizonepeta
undecylenic acid
neem tree
nut grass
commiphora
caesalpinia crista
pau d'arco
lemongrass
morinda
oriental arborvitae
zanthoxylum
polyphenols
eucalyptus
camphor oil
menthol oil
melaleuca alternifolia
geranium
10-Undecenoic Acid
3-Phenyllactic Acid
Agarikon Mushroom
Alpha-terpineol
Ardisia
Allicin
Anamu
Ajuga
Ampelopsis
Allyl Sulfide
Allyl isothiocyanate
Allium tuberosum
Alantolactone
Bee Propolis
Babchi
Baphicacanthus cusia
Barleria
Brazilian peppertree
Bisabolene
Bee hive
Borate
Black Nightshade
benzyl isothiocyanate
Borneol
Curry leaf
Caryophyllene
Calendula
Cinnamomum
coconut oil
Carvacrol
Cajuput
Citral
Centipeda
Chalcone
Copaiba Oil
Citronella
Dianthus
Euphorbia
Eugenol
Geraniol
Gnaphalium
Glyceryl monolaurate
gamma-terpinene
Garlic
Glyceryl caprylate caprate
Glechoma hederacea
Geranial
Hedyotis
Houttuynia
Henna
Herb Robert
Indian Fagonia
Jojoba Oil
Kefir
Lebbek
Litsea
Lichen
Laggera pterodonta
Lodhtree
Lantana camara
Leptospermum scoparium
Liverwort
Linalool
Labdanum
Mountain Pepper
Mustard
Melia
Mangostin
Mahonia
Marigold
Marking Nut Tree
Macaranga indica
Naphthoquinones
Oroxylum indicum
Onosma bracteatum
Propolis
Pentacyclic triterpenoids
Phlorotannins
Plumbago zeylanica
Plectranthus amboinicus
Polygodial
Rue
Sophora
Self-Heal
Salvia
Soapberry
Sandalwood
Sapindus mukorossi
Stereospermum
Sumac
Sulfur
Storax
Terpinen-4-ol
Thuja
Thymol
Thaumatococcus daniellii
Tulbaghia
Tea Tree Oil
Thiosulfinate
Terpinolene
Violet
Wrightia tinctoria
Water Pepper
Winter Savory
Zingiberene

Products containing Thiosulfinate

We currently have no products on Vitabase that contain this ingredient.