Evidence supporting the use of: Thiosulfinate
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Thiosulfinates are a class of organosulfur compounds most notably found in garlic (Allium sativum) and onions, with allicin being the best-known thiosulfinate. Their use in supporting or treating fungal infections is justified by a moderate level of scientific evidence. Several in vitro studies have demonstrated that allicin and related thiosulfinates possess broad-spectrum antifungal activity, notably against Candida species, Aspergillus, and some dermatophytes. The mechanism of action is thought to involve the inhibition of fungal enzymes through the interaction with thiol groups, leading to cell membrane disruption and reduced fungal viability.

However, while laboratory and animal studies are promising, robust clinical evidence in humans is limited. Some small-scale clinical trials and case reports suggest benefits in treating superficial fungal infections (such as athlete’s foot and oral candidiasis), but large, well-controlled studies are lacking. Thiosulfinates are not generally recommended as first-line therapy in clinical guidelines, likely due to variability in bioavailability, formulation, and the lack of standardized dosing. Traditional medicine systems have used garlic extracts for various infections, but the scientific focus is specifically on thiosulfinates for their antifungal properties. Overall, thiosulfinates show promise as adjunctive agents or topical treatments, but more rigorous human trials are needed to establish efficacy and safety for the treatment of fungal infections.

More about Thiosulfinate
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Products containing Thiosulfinate

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