Evidence supporting the use of: Thymol
For the health condition: Fungal Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Thymol is a natural monoterpene phenol found in thyme oil and has been traditionally used as an antiseptic and preservative. Its antifungal properties are supported by a growing body of scientific research, primarily in vitro (laboratory) and some in vivo (animal and topical human) studies. Thymol disrupts fungal cell membranes, leading to leakage of cell contents and subsequent cell death. Studies have demonstrated its efficacy against a range of fungal pathogens, including Candida albicans, Aspergillus species, and dermatophytes responsible for skin infections like athlete’s foot.

For example, a 2016 review published in Frontiers in Pharmacology highlights thymol’s antifungal activity and potential as a therapeutic agent, particularly in combination with other antifungals, which may help overcome resistance. Another study in the Journal of Medical Microbiology (2007) showed that thymol exhibited fungicidal activity against Candida species at concentrations lower than those toxic to human cells.

However, most evidence comes from laboratory research, with limited clinical trials confirming its efficacy and safety in humans for treating fungal infections. Thymol is included in some over-the-counter topical antifungal products, reflecting both its traditional and scientific support. Overall, while the evidence is promising and mechanistically sound, it remains primarily preclinical, justifying a moderate evidence rating.

More about Thymol
More about Fungal Infections

Products containing Thymol

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