Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Undecylenic acid is an unsaturated fatty acid derived from castor oil. It has been used as an antifungal agent, particularly for skin infections such as athlete’s foot (tinea pedis), ringworm (tinea corporis), and other superficial mycoses. The scientific basis for its use stems from its ability to disrupt fungal cell membranes, leading to leakage of cellular contents and eventual cell death. Multiple in vitro studies have demonstrated that undecylenic acid and its salts inhibit the growth of various dermatophytes, including species of Trichophyton and Epidermophyton. The U.S. Food and Drug Administration (FDA) recognizes undecylenic acid as an over-the-counter antifungal agent for topical use, further supporting its acceptance in clinical practice.

However, the quality and quantity of clinical trials in humans remain moderate. Most evidence comes from laboratory studies and older clinical reports, with few large, well-controlled trials. Compared to other antifungals, such as azoles or allylamines, undecylenic acid may be less potent but is generally safe and well-tolerated for mild infections. Its use is primarily justified for superficial fungal infections and not for systemic or severe infections. In summary, while undecylenic acid is not the most potent antifungal available, there is reasonable scientific validation for its use as a topical agent for minor fungal skin infections.

More about Undecylenic acid
More about Fungal Infections

Other ingredients used for Fungal Infections

Other health conditions supported by Undecylenic acid

Products containing Undecylenic acid

Pure Encapsulations A.C. Formula II
Thorne Undecylenic Acid Formula