7-Methoxyflavone is a naturally occurring flavonoid found in various plants, including Kaempferia parviflora and some citrus species. Its use to "support the GABA body system" is based on emerging scientific research, primarily from preclinical (in vitro and animal) studies. Several studies have demonstrated that 7-methoxyflavone and structurally related polymethoxyflavones can modulate GABA_A receptors, which are the primary inhibitory neurotransmitter receptors in the central nervous system. For example, research published in the journal Bioorganic & Medicinal Chemistry Letters (2012) found that 7-methoxyflavone and analogs could potentiate GABA-induced chloride currents in cultured neurons, suggesting a positive allosteric modulatory effect similar to that of benzodiazepines, though generally much weaker.

These properties suggest potential anxiolytic (anxiety-reducing) or sedative effects, and animal studies have reported mild anxiolytic actions. However, there are no robust clinical trials in humans confirming efficacy or safety, and the evidence is limited both in quantity and quality. Its use is therefore justified by early scientific investigation rather than a long tradition in herbal medicine or strong clinical validation. The evidence rating here is moderate to low (2/5) due to the lack of definitive human studies.