Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Albizia julibrissin, commonly known as the silk tree or mimosa, has a long history of use in traditional Chinese medicine (TCM). In TCM, the bark and flowers (referred to as He Huan Pi and He Huan Hua, respectively) are used to calm the spirit, relieve emotional constraint, and support restful sleep. These effects are conceptually linked to what modern science refers to as the GABAergic system, though the traditional descriptions are not biochemically specific. The plant is said to nourish the heart and calm the mind, which aligns with its historical use for anxiety, insomnia, and mood disturbances.

Scientific validation for Albizia julibrissin’s direct impact on the GABA (gamma-aminobutyric acid) system is limited. Preliminary studies have identified several bioactive compounds in the plant, including saponins and flavonoids, that may contribute to its sedative and anxiolytic effects in animal models. However, evidence for a direct mechanism involving the GABA system is sparse, and human clinical data are lacking. Most references to its GABA-related activity are extrapolated from its calming effects observed in traditional use and animal studies, rather than demonstrated modulation of GABA receptors.

In summary, the use of Albizia julibrissin to support the “GABA body system” is justified primarily by traditional and historical use, with limited scientific support. More rigorous research is needed to clarify its precise mechanism of action and efficacy in humans.

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