Evidence supporting the use of: Chamomile (Matricaria chamomilla)
For the body system: GABA

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Chamomile (Matricaria chamomilla) is traditionally used as a mild sedative and anxiolytic, and modern research has provided some scientific validation for its effects on the gamma-aminobutyric acid (GABA) system. Several in vitro and animal studies have shown that apigenin, a flavonoid found in chamomile, binds to benzodiazepine receptors in the brain, which are part of the GABAA receptor complex. This suggests that chamomile may exert calming and anxiolytic effects by modulating GABAergic neurotransmission, similar to how benzodiazepines work, though with milder potency and fewer side effects. Human clinical studies, though limited, have shown that chamomile extracts can reduce symptoms of generalized anxiety disorder and improve sleep quality, supporting its traditional use for relaxation and insomnia. However, while these findings are promising, the direct evidence for GABA modulation in humans is not as strong as in animal or laboratory studies. The overall evidence base is moderate, with a mixture of traditional support and preliminary scientific validation, but more rigorous, large-scale human studies are needed to confirm its efficacy and clarify its mechanisms of action on the GABA system.

More about Chamomile (Matricaria chamomilla)
More about GABA

Products containing Chamomile (Matricaria chamomilla)

We currently have no products on Vitabase that contain this ingredient.