Evidence supporting the use of: Chamomile (Matricaria recutita)
For the body system: GABA

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Chamomile (Matricaria recutita) has a long history of traditional use as a calming herb, often employed in teas and extracts for anxiety and sleep support. In recent years, scientific research has explored its potential effects on the gamma-aminobutyric acid (GABA) system, which is the primary inhibitory neurotransmitter system in the central nervous system and plays a key role in anxiety regulation. Some in vitro and animal studies have shown that apigenin, a flavonoid compound found in chamomile, can bind to benzodiazepine receptors on the GABAA receptor complex, suggesting a GABAergic mechanism of action. This interaction may underlie chamomile's anxiolytic (anxiety-reducing) effects. Human clinical studies are limited, but a few small trials have found that standardized chamomile extracts may reduce symptoms of mild to moderate generalized anxiety disorder, though these trials do not directly confirm modulation of the GABA system in humans. Overall, while there is scientific plausibility for chamomile's action on the GABA system, the evidence is moderate and largely preclinical, with some supportive but indirect findings in human studies.

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