Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dihydromyricetin (DHM), a flavonoid compound found in the Japanese raisin tree (Hovenia dulcis), has garnered scientific interest for its effects on the GABAergic system. Preclinical animal studies, most notably a 2012 study by Liang et al. in The Journal of Neuroscience, have shown that DHM can counteract the effects of alcohol intoxication and withdrawal. Mechanistically, DHM appears to modulate GABA_A receptors, specifically by antagonizing alcohol’s enhancement of GABAergic transmission, which may explain its potential in reducing alcohol-induced sedation and dependence. While these results are promising, it is important to note that the majority of evidence is based on rodent models and limited in vitro analyses. There are currently no large-scale human clinical trials confirming DHM’s efficacy or safety for supporting GABA function or treating alcohol-related disorders. Traditional use of Hovenia dulcis fruit in East Asian medicine has focused on liver health and hangover relief, but explicit targeting of the GABA system is not well documented in historical texts. In summary, there is early-stage scientific evidence supporting DHM’s interaction with the GABAergic system, primarily from animal studies, but clinical validation in humans is lacking. Thus, the scientific evidence is rated as moderate but preliminary (2/5) for supporting the GABA body system.

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