Synopsis

Source of validity: Scientific
Rating (out of 5): 3

English Lavender (Lavandula angustifolia) has been traditionally used for its calming effects, but in recent decades, scientific interest has focused on its potential interaction with the GABAergic system, which regulates anxiety and mood. Several preclinical studies have demonstrated that lavender oil and its constituents, such as linalool and linalyl acetate, can bind to GABA-A receptors and modulate their activity. This action is believed to underlie lavender's anxiolytic and sedative effects.

Clinical evidence also exists: a standardized oral lavender oil preparation (Silexan) has shown efficacy in multiple randomized, placebo-controlled trials for generalized anxiety disorder and subsyndromal anxiety, with an effect size comparable to low-dose benzodiazepines and SSRIs. Neuroimaging studies have shown that lavender oil can decrease activity in brain regions associated with anxiety. The proposed mechanism involves increased GABAergic neurotransmission, though some studies suggest additional serotonergic and glutamatergic involvement.

While the evidence is strongest for symptom relief of anxiety (which is regulated in part through GABAergic pathways), direct evidence of lavender specifically increasing GABA levels in humans is limited. Nevertheless, the converging lines of preclinical and clinical research justify the use of English Lavender as a GABA system modulator, though more studies would solidify the mechanistic details. Thus, the evidence is significant but not yet definitive, warranting a moderate rating.

More about English Lavender
More about GABA

Other ingredients that support GABA

Other body systems supported by English Lavender

Products containing English Lavender