Evidence supporting the use of: Erythrina (unspecified)
For the body system: GABA

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Erythrina species, commonly known as coral trees, have a long history of traditional use in various cultures, particularly in Central and South America. Traditionally, extracts from Erythrina species (such as Erythrina mulungu and Erythrina verna) have been used as sedatives, anxiolytics, and sleep aids. These uses are attributed to their purported calming effects on the nervous system, which has led to the association with support of the GABA (gamma-aminobutyric acid) system, a primary inhibitory neurotransmitter pathway in the brain. However, scientific studies directly confirming Erythrina’s action on the GABA system in humans are limited. Some preclinical studies and phytochemical analyses suggest that certain alkaloids in Erythrina may interact with GABAA receptors or have CNS depressant activity, but robust clinical data is lacking. Thus, while there is a clear tradition of use for calming and sedative purposes, and some preliminary pharmacological rationale, strong scientific validation is not yet established. The evidence supporting its effectiveness for GABA system modulation is therefore rated as moderate (2/5), based primarily on traditional use and limited supportive laboratory studies.

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