Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Kanna (Sceletium tortuosum) is a succulent plant native to South Africa that has a long history of traditional use as a mood enhancer and stress reliever. Modern scientific interest has centered on its potential effects on the central nervous system, particularly its interaction with neurotransmitters such as serotonin and GABA (gamma-aminobutyric acid). Several in vitro and animal studies suggest that alkaloids in kanna, such as mesembrine, may function as serotonin reuptake inhibitors and have some modulatory effect on GABAergic neurotransmission. However, the evidence for direct support of the GABA system is limited, primarily stemming from laboratory studies showing weak inhibition of the enzyme phosphodiesterase-4 (PDE4) and minor modulation of GABA receptor activity. Human clinical trials on kanna are scarce, and those available focus mainly on its anxiolytic (anxiety-reducing) and mood-lifting properties rather than direct GABAergic effects.

Overall, while kanna does have some scientific evidence supporting its use for mood and anxiety, the evidence supporting its use specifically for GABA system support is preliminary and modest. Further clinical research is needed before strong conclusions can be drawn.

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