Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Kavalactones are the primary active compounds found in the root of the kava plant (Piper methysticum). There is a moderate level of scientific evidence supporting their use in modulating the GABAergic system in the human body. Kavalactones are believed to exert anxiolytic (anxiety-reducing) effects primarily by interacting with gamma-aminobutyric acid (GABA) receptors in the brain. GABA is the main inhibitory neurotransmitter in the central nervous system, and its activation leads to calming and sedative effects.

Preclinical studies have demonstrated that kavalactones can potentiate GABA receptor activity, though not by directly binding to the same site as benzodiazepines. Instead, they appear to modulate GABA transmission indirectly, which may account for their anxiety-reducing properties without causing significant sedation or dependence. Several randomized controlled trials and meta-analyses (e.g., Sarris et al., 2011; Pittler & Ernst, 2003) have found that kava extracts can be more effective than placebo for reducing symptoms of mild to moderate anxiety, supporting its use as a natural anxiolytic. However, studies vary in quality, and there are concerns regarding hepatotoxicity with long-term or high-dose use.

In summary, kavalactones are used to support the GABA system with a moderate degree of scientific validation, particularly for anxiety. Their use is supported by both traditional practices in the South Pacific and by clinical research, though safety concerns limit widespread acceptance.

More about Kavalactones
More about GABA

Other ingredients that support GABA

Other body systems supported by Kavalactones

Products containing Kavalactones