Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lavandula (commonly known as lavender) is traditionally used for its calming effects, but there is also scientific evidence supporting its influence on the GABA (gamma-aminobutyric acid) system, which is the primary inhibitory neurotransmitter system in the central nervous system. Several studies have shown that lavender oil, particularly the oral preparation known as Silexan, can have anxiolytic (anxiety-reducing) effects. These effects are believed to be mediated in part through modulation of the GABAergic system. Preclinical research suggests that lavender oil compounds, such as linalool and linalyl acetate, may interact with NMDA receptors and increase GABAergic neurotransmission, thereby producing calming effects. Clinical trials have found lavender oil preparations to be more effective than placebo in reducing symptoms of anxiety, and in some cases, comparable to low-dose lorazepam (a benzodiazepine, which directly modulates GABA activity).

However, while these findings are promising, the exact mechanisms are not fully elucidated, and the overall strength of evidence is moderate rather than robust. Most studies focus on anxiety and related conditions rather than direct measurement of GABA levels or function in humans. Therefore, lavender’s use to support the GABA system is backed by both mechanistic and clinical data, but more research is needed to fully clarify its role and efficacy.

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