Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Mexican valerian (Valeriana edulis or sometimes Valeriana mexicana) has traditionally been used as a calming agent and sleep aid in Mexican and Central American herbal medicine. Its use is similar to that of common valerian (Valeriana officinalis), which is better studied. The root of Mexican valerian is believed to exert mild sedative effects, and it is commonly used in folk remedies for anxiety, insomnia, and nervousness. This traditional use is likely related to the plant's content of valepotriates and other compounds that may influence the central nervous system.

The connection to the GABA (gamma-aminobutyric acid) system arises because valerian species have been shown, in laboratory studies (mainly with V. officinalis), to enhance GABAergic activity, which is associated with calming and anxiolytic effects. However, direct scientific studies specifically examining Mexican valerian and its effects on the GABA system are scarce. Most scientific validation involves Valeriana officinalis, not Mexican valerian. Therefore, while there is a historical precedent for using Mexican valerian for calming and sleep, and a plausible mechanism based on related species, robust scientific evidence for its direct effect on the GABA system is lacking. Thus, its use is primarily justified by tradition, with weak scientific evidence specific to this species.

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