Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Uncaria rhynchophylla, also known as Gou Teng, has a long history of use in Traditional Chinese Medicine (TCM) primarily for calming internal wind, treating headache, dizziness, and convulsions. Its use to support the GABA (gamma-aminobutyric acid) body system is rooted in its traditional reputation for calming effects and anticonvulsant properties. Modern pharmacological studies have identified several alkaloids in Uncaria rhynchophylla, such as rhynchophylline and isorhynchophylline, which exhibit neuroprotective and anti-epileptic activities in animal models. Some preclinical studies suggest that extracts of this plant may modulate neurotransmitter activity, potentially influencing GABAergic signaling and reducing neuronal excitability. However, direct evidence demonstrating that Uncaria rhynchophylla specifically supports or enhances the GABA system in humans is limited. Most scientific investigations remain preliminary, focusing on animal models or in vitro assays. Consequently, while its calming effects are recognized in traditional practices and supported by some early pharmacological findings, robust clinical evidence validating its use for GABA system support in humans is lacking. Thus, current justification for its use in this context is primarily traditional, with emerging but not yet definitive scientific interest.

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