Evidence supporting the use of: Bupleurum
For the body system: Gall Bladder

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Bupleurum (Bupleurum chinense) is an herb widely used in Traditional Chinese Medicine (TCM), where it is known as Chai Hu. Historically, Bupleurum has been used to "soothe the liver" and "regulate qi," concepts that are often linked in TCM to supporting the health of the liver and gall bladder systems. In classic TCM formulas such as Xiao Chai Hu Tang ("Minor Bupleurum Decoction"), Bupleurum is used for conditions believed to involve stagnation or dysfunction of the liver and gall bladder, manifesting as symptoms like chest discomfort, irritability, or digestive disturbances.

From a scientific standpoint, Bupleurum contains active compounds called saikosaponins, which have demonstrated anti-inflammatory, hepatoprotective, and immunomodulatory effects in laboratory studies. However, there is limited direct clinical evidence in modern medicine specifically supporting Bupleurum's effect on gall bladder function (such as bile flow or gallstone prevention) in humans. Most research focuses on liver protection or anti-inflammatory effects rather than gall bladder health per se.

In summary, the use of Bupleurum to support the gall bladder is justified primarily by traditional use within TCM, with formulas and theory supporting its role in this body system. Scientific research provides indirect support through related but not gall bladder–specific effects. Therefore, the evidence level is rated as 3, reflecting a strong traditional basis but limited direct scientific validation for gall bladder support.

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