Evidence supporting the use of: Bupleurum (unspecified)
For the body system: Gall Bladder

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Bupleurum, particularly Bupleurum chinense (Chai Hu), has been used for centuries in Traditional Chinese Medicine (TCM) to support liver and gall bladder health. In classic TCM formulations such as Xiao Chai Hu Tang (Minor Bupleurum Decoction), it is a key herb indicated for “harmonizing” the liver and gall bladder, often prescribed for symptoms believed to be related to liver qi stagnation or gall bladder disharmony, such as chest and flank pain, irritability, and digestive discomfort. The traditional rationale is based on TCM concepts rather than modern anatomical or physiological understanding of the gall bladder.

Scientific evidence for Bupleurum’s effects on the gall bladder specifically is limited. Most modern research focuses on its anti-inflammatory and immunomodulatory effects, hepatoprotective (liver-protective) properties, and potential benefits in liver disorders. There are animal studies suggesting Bupleurum extracts may stimulate bile flow (choleretic effect), which could theoretically influence gall bladder function, but these studies are preliminary and not directly correlated with clinical gall bladder disease. No robust clinical trials have established Bupleurum as an effective agent for gall bladder health in humans.

In summary, the use of Bupleurum to support the gall bladder is justified primarily by traditional use in TCM, with limited and indirect scientific evidence related to bile flow but not specifically to gall bladder health or disease in humans.

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