Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Cascara sagrada (Rhamnus purshiana) has a long history of traditional use, primarily as a natural laxative to relieve constipation. Within herbal medicine systems, particularly among Native American groups and later in Western herbalism, cascara sagrada has sometimes been included in formulas intended to "cleanse" or "support" the liver and gall bladder, although this association is indirect. The rationale is that by promoting regular bowel movements and bile flow, digestive organs, including the gall bladder, may function more efficiently. However, traditional references to cascara sagrada specifically supporting the gall bladder are sparse compared to its well-documented use as a laxative. There is little scientific evidence to directly support cascara sagrada’s benefit for gall bladder health or function. Most clinical research and pharmacological data focus on its role as a stimulant laxative, where its active components (anthraquinones) stimulate peristalsis in the colon. No clinical trials or robust studies have demonstrated a specific benefit to the gall bladder, such as preventing gallstones or improving bile composition. Thus, while its inclusion in gall bladder support formulas is rooted in traditional herbal practice, there is minimal direct traditional or scientific evidence for this specific use.

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