Evidence supporting the use of: Cholic acid
For the body system: Gall Bladder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Cholic acid is a primary bile acid that is naturally produced in the liver and is a critical component in the digestion and absorption of dietary fats. Its use in supporting the gall bladder and biliary system is scientifically validated, particularly in the context of rare bile acid synthesis disorders. Cholic acid supplementation is FDA-approved for the treatment of patients with bile acid synthesis defects due to single enzyme deficiencies (such as 3β-hydroxy-Δ5-C27-steroid oxidoreductase deficiency and Δ4-3-oxosteroid 5β-reductase deficiency). In these rare genetic conditions, the body cannot produce normal bile acids, leading to accumulation of abnormal intermediates that can damage the liver and gall bladder. Supplementing with cholic acid restores the normal feedback inhibition of bile acid synthesis, reduces toxic intermediates, and improves bile flow, thereby supporting normal function of the gall bladder and biliary tract.

However, outside of these specific medical indications, there is limited evidence supporting the use of cholic acid supplements in the general population for gall bladder health. The role of cholic acid in over-the-counter supplements for supporting the gall bladder is not well established. Most clinical research focuses on its therapeutic use in rare metabolic disorders rather than general wellness or prevention of gall bladder disease.

In summary, cholic acid's use to support the gall bladder is scientifically validated but is primarily limited to specific inherited disorders of bile acid synthesis, rather than general support for the average individual.

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